Comment

. 2020 Sep;69(9):1713-1715.

doi: 10.1136/gutjnl-2019-319729. Epub 2019 Sep 10.

Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis

Eszter Hegyi^{1

2

3}, Anna Zsófia Tóth¹, Áron Vincze⁴, Andrea Szentesi^{2

5}, Péter Hegyi^#^{2

3}, Miklós Sahin-Tóth^#^{6

7}

Affiliations

¹ Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M Goldman School of Dental Medicine, Boston, Massachusetts, USA.
² Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary.
³ Szentágothai Research Centre, University of Pécs Medical School, Pécs, Hungary.
⁴ First Department of Medicine, University of Pécs Medical School, Pécs, Hungary.
⁵ First Department of Medicine, University of Szeged, Szeged, Hungary.
⁶ Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M Goldman School of Dental Medicine, Boston, Massachusetts, USA msahintoth@mednet.ucla.edu.
⁷ Department of Surgery, UCLA, Los Angeles, California, USA.

^# Contributed equally.

PMID: 31506327
PMCID: PMC7062586
DOI: 10.1136/gutjnl-2019-319729

Comment

Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis

Eszter Hegyi et al. Gut. 2020 Sep.

. 2020 Sep;69(9):1713-1715.

doi: 10.1136/gutjnl-2019-319729. Epub 2019 Sep 10.

Authors

Eszter Hegyi^{1

2

3}, Anna Zsófia Tóth¹, Áron Vincze⁴, Andrea Szentesi^{2

5}, Péter Hegyi^#^{2

3}, Miklós Sahin-Tóth^#^{6

7}

Affiliations

¹ Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M Goldman School of Dental Medicine, Boston, Massachusetts, USA.
² Institute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary.
³ Szentágothai Research Centre, University of Pécs Medical School, Pécs, Hungary.
⁴ First Department of Medicine, University of Pécs Medical School, Pécs, Hungary.
⁵ First Department of Medicine, University of Szeged, Szeged, Hungary.
⁶ Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M Goldman School of Dental Medicine, Boston, Massachusetts, USA msahintoth@mednet.ucla.edu.
⁷ Department of Surgery, UCLA, Los Angeles, California, USA.

^# Contributed equally.

PMID: 31506327
PMCID: PMC7062586
DOI: 10.1136/gutjnl-2019-319729

No abstract available

Keywords: GENETIC POLYMORPHISMS; GENETICS; PANCREAS; PANCREATIC ENZYMES; PANCREATITIS.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

**Figure 1.**
Linkage of variants of the *PRSS1-PRSS2* haplotype within the *PRSS1* promoter and coding region. Linkage disequilibrium between the four SNPs rs10273639 (c.-408C>T), rs4726576 (c.-204C>A), rs6666 (c.486C>T), and rs6667 (c.738C>T) in European populations was calculated. Data was taken from Phase 3 (Version 5) of the 1000 Genomes Project using the LDlink website (https://ldlink.nci.nih.gov/).

See this image and copyright information in PMC

Comment in

Transgenic expression of human PRSS2 exacerbates pancreatitis in mice.
Wan J, Haddock A, Edenfield B, Ji B, Bi Y. Wan J, et al. Gut. 2020 Nov;69(11):2051-2052. doi: 10.1136/gutjnl-2019-320399. Epub 2020 Jan 23. Gut. 2020. PMID: 31974135 Free PMC article. No abstract available.
Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner.
Wang YC, Mao XT, Yu D, Mao SH, Li ZS, Zou WB, Liao Z. Wang YC, et al. Gut. 2022 Nov;71(11):2369-2371. doi: 10.1136/gutjnl-2021-326670. Epub 2022 Jan 7. Gut. 2022. PMID: 34996825 No abstract available.
Alcohol predisposes obese mice to acute pancreatitis via adipose triglyceride lipase-dependent visceral adipocyte lipolysis.
Yang X, Yao L, Dai L, Yuan M, He W, Liu T, Fu X, Xue J, Sutton R, Xia Q, Huang W. Yang X, et al. Gut. 2023 Jan;72(1):212-214. doi: 10.1136/gutjnl-2022-326958. Epub 2022 Apr 22. Gut. 2023. PMID: 35459708 Free PMC article. No abstract available.

Comment on

Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.
Derikx MH, Kovacs P, Scholz M, Masson E, Chen JM, Ruffert C, Lichtner P, Te Morsche RH, Cavestro GM, Férec C, Drenth JP, Witt H, Rosendahl J; PanEuropean Working group on Alcoholic Chronic Pancreatitis Members and Collaborators. Derikx MH, et al. Gut. 2015 Sep;64(9):1426-33. doi: 10.1136/gutjnl-2014-307453. Epub 2014 Sep 24. Gut. 2015. PMID: 25253127
Identification of a functional PRSS1 promoter variant in linkage disequilibrium with the chronic pancreatitis-protecting rs10273639.
Boulling A, Sato M, Masson E, Génin E, Chen JM, Férec C. Boulling A, et al. Gut. 2015 Nov;64(11):1837-8. doi: 10.1136/gutjnl-2015-310254. Epub 2015 Aug 5. Gut. 2015. PMID: 26246244 No abstract available.
PRSS1 copy number variants and promoter polymorphisms in pancreatitis: common pathogenetic mechanism, different genetic effects.
Masson E, Chen JM, Cooper DN, Férec C. Masson E, et al. Gut. 2018 Mar;67(3):592-593. doi: 10.1136/gutjnl-2017-314443. Epub 2017 Jun 10. Gut. 2018. PMID: 28601843 No abstract available.

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Role of the Common PRSS1-PRSS2 Haplotype in Alcoholic and Non-Alcoholic Chronic Pancreatitis: Meta- and Re-Analyses.
Herzig AF, Génin E, Cooper DN, Masson E, Férec C, Chen JM. Herzig AF, et al. Genes (Basel). 2020 Nov 13;11(11):1349. doi: 10.3390/genes11111349. Genes (Basel). 2020. PMID: 33202925 Free PMC article.
Pre-existing, Concurrent/Early-Onset, and Late-Onset Diabetes in Chronic Pancreatitis: Do Outcomes Differ?
Zuberi SA, Shah I, Bocchino RL, Ahmed A, Freedman SD, Kothari DJ, Sheth SG. Zuberi SA, et al. Dig Dis Sci. 2023 Apr;68(4):1519-1524. doi: 10.1007/s10620-022-07742-y. Epub 2022 Nov 1. Dig Dis Sci. 2023. PMID: 36318379 Review.
Risk of chronic pancreatitis in carriers of the c.180C>T (p.Gly60=) CTRC variant: case-control studies and meta-analysis.
Berke G, Beer S, Gede N, Takáts A, Szentesi A, Hegyi P, Rosendahl J, Sahin-Tóth M, Németh BC, Hegyi E. Berke G, et al. Pancreatology. 2023 Aug;23(5):481-490. doi: 10.1016/j.pan.2023.05.013. Epub 2023 May 29. Pancreatology. 2023. PMID: 37321941 Free PMC article.
Transgenic expression of human PRSS2 exacerbates pancreatitis in mice.
Wan J, Haddock A, Edenfield B, Ji B, Bi Y. Wan J, et al. Gut. 2020 Nov;69(11):2051-2052. doi: 10.1136/gutjnl-2019-320399. Epub 2020 Jan 23. Gut. 2020. PMID: 31974135 Free PMC article. No abstract available.
A Label-Free Fluorescence Aptasensor Based on G-Quadruplex/Thioflavin T Complex for the Detection of Trypsin.
Gu P, Lu Y, Li S, Ma C. Gu P, et al. Molecules. 2022 Sep 18;27(18):6093. doi: 10.3390/molecules27186093. Molecules. 2022. PMID: 36144829 Free PMC article.

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References

1. Derikx MH, Kovacs P, Scholz M, et al. Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. Gut 2015;64:1426–1433. - PubMed
1. Boulling A, Sato M, Masson E, et al. Identification of a functional PRSS1 promoter variant in linkage disequilibrium with the chronic pancreatitis-protecting rs10273639. Gut 2015;64:1837–1838. - PubMed
1. Masson E, Chen JM, Cooper DN, Férec C. PRSS1 copy number variants and promoter polymorphisms in pancreatitis: common pathogenetic mechanism, different genetic effects. Gut 2018;67:592–593. - PubMed
1. Whitcomb DC, LaRusch J, Krasinskas AM, et al. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet 2012;44:1349–1354. - PMC - PubMed
1. Rinderknecht H, Stace NH, Renner IG. Effects of chronic alcohol abuse on exocrine pancreatic secretion in man. Dig Dis Sci 1985;30:65–71. - PubMed

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Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis

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Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis

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