Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis
- PMID: 31506327
- PMCID: PMC7062586
- DOI: 10.1136/gutjnl-2019-319729
Alcohol-dependent effect of PRSS1-PRSS2 haplotype in chronic pancreatitis
Keywords: GENETIC POLYMORPHISMS; GENETICS; PANCREAS; PANCREATIC ENZYMES; PANCREATITIS.
Conflict of interest statement
Competing interests: None declared.
Figures

Comment in
-
Transgenic expression of human PRSS2 exacerbates pancreatitis in mice.Gut. 2020 Nov;69(11):2051-2052. doi: 10.1136/gutjnl-2019-320399. Epub 2020 Jan 23. Gut. 2020. PMID: 31974135 Free PMC article. No abstract available.
-
Alcohol amplifies the association between common variants at PRSS1-PRSS2 locus and chronic pancreatitis in a dose-dependent manner.Gut. 2022 Nov;71(11):2369-2371. doi: 10.1136/gutjnl-2021-326670. Epub 2022 Jan 7. Gut. 2022. PMID: 34996825 No abstract available.
-
Alcohol predisposes obese mice to acute pancreatitis via adipose triglyceride lipase-dependent visceral adipocyte lipolysis.Gut. 2023 Jan;72(1):212-214. doi: 10.1136/gutjnl-2022-326958. Epub 2022 Apr 22. Gut. 2023. PMID: 35459708 Free PMC article. No abstract available.
Comment on
-
Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.Gut. 2015 Sep;64(9):1426-33. doi: 10.1136/gutjnl-2014-307453. Epub 2014 Sep 24. Gut. 2015. PMID: 25253127
-
Identification of a functional PRSS1 promoter variant in linkage disequilibrium with the chronic pancreatitis-protecting rs10273639.Gut. 2015 Nov;64(11):1837-8. doi: 10.1136/gutjnl-2015-310254. Epub 2015 Aug 5. Gut. 2015. PMID: 26246244 No abstract available.
-
PRSS1 copy number variants and promoter polymorphisms in pancreatitis: common pathogenetic mechanism, different genetic effects.Gut. 2018 Mar;67(3):592-593. doi: 10.1136/gutjnl-2017-314443. Epub 2017 Jun 10. Gut. 2018. PMID: 28601843 No abstract available.
References
-
- Derikx MH, Kovacs P, Scholz M, et al. Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study. Gut 2015;64:1426–1433. - PubMed
-
- Boulling A, Sato M, Masson E, et al. Identification of a functional PRSS1 promoter variant in linkage disequilibrium with the chronic pancreatitis-protecting rs10273639. Gut 2015;64:1837–1838. - PubMed
-
- Masson E, Chen JM, Cooper DN, Férec C. PRSS1 copy number variants and promoter polymorphisms in pancreatitis: common pathogenetic mechanism, different genetic effects. Gut 2018;67:592–593. - PubMed
-
- Rinderknecht H, Stace NH, Renner IG. Effects of chronic alcohol abuse on exocrine pancreatic secretion in man. Dig Dis Sci 1985;30:65–71. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical