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Comment
. 2019 Oct;37(10):1129-1130.
doi: 10.1038/s41587-019-0269-x.

Modeling human lung infections in mice

Hergen Spits  1 , Julien Villaudy  2
Affiliations
Comment

Modeling human lung infections in mice

Hergen Spits et al. Nat Biotechnol. 2019 Oct.

Abstract

Respiratory pathogens and the human immune response they elicit can now be studied in humanized mice.

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Conflict of interest statement

J.V. is an employee of and stockholder in AIMM Therapeutics. H.S. owns stock in AIMM Therapeutics and consults for GlaxoSmithKline.

Figures

Fig. 1
Fig. 1. Humanized mice to study human-tropic pathogens.
Various human cell types have been transplanted into immunodeficient mice to study diverse pathogens and diseases. Human immune system (HIS) mice are engrafted with hematopoietic stem cells. Bone marrow–liver–thymic (BLT) mice are engrafted with hematopoietic stem cells, fetal liver and fetal thymus from the same donor. HuHEP mice are engrafted with human liver cells to study hepatotropic viruses and, when combined with human erythrocytes, the replication cycle of the malaria parasite. BLT-L mice, now developed by Wahl et al., are engrafted with lung cells, with or without autologous immune cells, to study respiratory viruses.
See this image and copyright information in PMC

Comment on

  • Precision mouse models with expanded tropism for human pathogens.
    Wahl A, De C, Abad Fernandez M, Lenarcic EM, Xu Y, Cockrell AS, Cleary RA, Johnson CE, Schramm NJ, Rank LM, Newsome IG, Vincent HA, Sanders W, Aguilera-Sandoval CR, Boone A, Hildebrand WH, Dayton PA, Baric RS, Pickles RJ, Braunstein M, Moorman NJ, Goonetilleke N, Victor Garcia J. Wahl A, et al. Nat Biotechnol. 2019 Oct;37(10):1163-1173. doi: 10.1038/s41587-019-0225-9. Epub 2019 Aug 26. Nat Biotechnol. 2019. PMID: 31451733 Free PMC article.

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