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Randomized Controlled Trial
. 2020 Sep;27(3):490-506.
doi: 10.1007/s10880-019-09649-9.

Psychological Outcomes of a Cognitive Behavioral Therapy for Youth with Inflammatory Bowel Disease: Results of the HAPPY-IBD Randomized Controlled Trial at 6- and 12-Month Follow-Up

Luuk Stapersma  1 , Gertrude van den Brink  2 , Jan van der Ende  1 , Eva M Szigethy  3 , Michael Groeneweg  4 , Frederieke H de Bruijne  5 , Manon H J Hillegers  1 , Johanna C Escher  2 , Elisabeth M W J Utens  6   7   8
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Randomized Controlled Trial

Psychological Outcomes of a Cognitive Behavioral Therapy for Youth with Inflammatory Bowel Disease: Results of the HAPPY-IBD Randomized Controlled Trial at 6- and 12-Month Follow-Up

Luuk Stapersma et al. J Clin Psychol Med Settings. 2020 Sep.

Abstract

Youth with inflammatory bowel disease (IBD) often experience psychological difficulties, such as anxiety and depression. This randomized controlled study tested whether a 3-month disease-specific cognitive behavioral therapy (CBT) in addition to standard medical care versus standard medical care only was effective in improving these youth's psychological outcomes. As this study was aimed at prevention, we included 70 youth (10-25 years) with IBD and symptoms of subclinical anxiety and/or depression, and measured psychological outcomes at 6- and 12-month follow-up. In general, participants in both groups showed improvements in anxiety, depression, health-related quality of life, social functioning, coping, and illness perceptions, sustained until 12 months follow-up. Overall, we found no differences between those receiving additional CBT and those receiving standard medical care only. We assume that this can be explained by the perceived low burden (both somatically and psychologically) or heightened awareness of psychological difficulties and IBD. ClinicalTrials.gov NCT02265588.

Keywords: Adolescents; Anxiety; Cognitive behavioral therapy; Depression; Inflammatory bowel disease; Psychological outcomes; Young adults.

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Conflict of interest statement

JCE received financial support from Merck Sharp & Dohme (research support), Janssen (advisory board), and AbbVie (advisory board). EMS received financial support from National Institutes of Health (grant), Crohn and Colitis Fund America (grant), AbbVie (consultancy), Merck (consultancy), iHOPE Network (consultancy), and royalties for book editing from APPI. For Luuk Stapersma, Gertrude van den Brink, Jan van der Ende, Michael Groeneweg, Frederieke H. de Bruijne, Manon H.J. Hillegers, Elisabeth M.W.J. Utens none were declared.

Figures

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CONSORT study flow chart
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Tree diagram PASCET-PI
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