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Review
. 2019 Aug 23:10:575.
doi: 10.3389/fendo.2019.00575. eCollection 2019.

Aldosterone in Gynecology and Its Involvement on the Risk of Hypertension in Pregnancy

Chiara Sabbadin  1 , Alessandra Andrisani  2 , Guido Ambrosini  2 , Luciana Bordin  3 , Gabriella Donà  3 , Jacopo Manso  1 , Filippo Ceccato  1 , Carla Scaroni  1 , Decio Armanini  1
Affiliations
Review

Aldosterone in Gynecology and Its Involvement on the Risk of Hypertension in Pregnancy

Chiara Sabbadin et al. Front Endocrinol (Lausanne). .

Abstract

Aldosterone is the main mineralocorticoid hormone, responsible of the regulation of fluid and electrolyte balance and blood pressure. It acts also as a pro-inflammatory factor responsible of an increased cardiovascular risk, independent from blood pressure values. After the discovery of mineralocorticoid receptor (MR) in mononuclear leukocytes, further studies supported its role in inflammatory and even autoimmune mechanisms underlying several diseases. In particular, recent studies reported a possible involvement of aldosterone in some gynecological conditions and diseases, characterized by inflammation, hypertension and increased cardio-metabolic risk, such as use of hormonal contraceptives, preeclampsia, polycystic ovary syndrome, uterine fibroids, and endometriosis. The aim of this mini-review is to report the possible involvement of aldosterone in all these gynecological conditions, suggesting different pathogenetic mechanisms and new target treatments of MR blockers for these diseases.

Keywords: aldosterone; endometriosis; hypertension; polycystyc ovary syndrome; preeclampsia; spironolactone.

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