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Comparative Study
. 1988 Dec;24(12):2202-7.

[Mechanisms of DNA repair disorders in human cells. Genome instability in lymphocytes of patients with myopathy related to DNA repair disorders]

[Article in Russian]
V V Chekova, N N Plotnikova, G N L'vova, T A Valikova, N N Il'inskikh
  • PMID: 3150757
Comparative Study

[Mechanisms of DNA repair disorders in human cells. Genome instability in lymphocytes of patients with myopathy related to DNA repair disorders]

[Article in Russian]
V V Chekova et al. Genetika. 1988 Dec.

Abstract

Increased level of cytogenetic damages was observed in lymphocytes of 10 patients with muscular dystrophy (Duchenne, Erba, Landuzi--Degerin). Analysis of DNA repair synthesis revealed inhibition of this process in lymphocytes of 10 patients observed. On the other hand, decreased reactivation of vaccinia virus and increased level of virus mutagenesis induced by 4-nitroquinoline-1-oxide and bleomycin was noted in the experiments with lymphocytes of 3 patients observed.

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