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Editorial
. 2019 Sep;15(3):167-170.
doi: 10.1183/20734735.0178-2019.

Protracted bacterial bronchitis is a precursor for bronchiectasis in children: myth or maxim?

Anne B Chang  1   2   3 , Julie M Marchant  1   2
Affiliations
Editorial

Protracted bacterial bronchitis is a precursor for bronchiectasis in children: myth or maxim?

Anne B Chang et al. Breathe (Sheff). 2019 Sep.

Abstract

Recognising the link between protracted bacterial bronchitis and bronchiectasis creates an opportunity to understand the pathobiology of early suppurative endobronchial lung disease and prospects for the development of effective and early interventions http://bit.ly/2K3ikI6.

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Conflict of interest statement

Conflict of interest: A.B. Chang reports grants from National Health and Medical Research Council, Australia related to the submitted work (multiple grants relating to cough, bronchiectasis and PBB). Other grants and interests from GSK (member of a data monitoring committee relating to an unlicensed vaccine), Up to Date (author of sections on paediatric cough) and BMJ Evidence Centre (author of two chapters on paediatric asthma with monies received by her institution) are outside the submitted work. Conflict of interest: J.M. Marchant reports other from Up to Date (author of sections on paediatric cough), outside the submitted work.

Figures

Figure 1
Figure 1
Using the pathobiological model, PBB, chronic suppurative lung disease (CSLD) and radiographically confirmed bronchiectasis probably represent different ends of a spectrum with similar underlying mechanisms of airway neutrophilia, endobronchial bacterial infection and impaired mucociliary clearance. Untreated it is likely some (but not all) children with PBB will progress to develop CSLD and some will ultimately develop bronchiectasis, initially reversible and subsequently irreversible if left to progress. There is a degree of overlap between each of the entities. Reproduced from [11] with permission from the publisher.
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References

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    1. Chang AB, Redding GJ, Everard ML. State of the Art - Chronic wet cough: protracted bronchitis, chronic suppurative lung disease and bronchiectasis. Pediatr Pulmonol 2008; 43: 519–531. - PubMed
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