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Meta-Analysis
. 2019 Sep 11;14(9):e0221076.
doi: 10.1371/journal.pone.0221076. eCollection 2019.

Relationship between Helicobacter pylori infection and obesity in Chinese adults: A systematic review with meta-analysis

Xinlan Xu  1 , Weide Li  1 , Lan Qin  1 , Wenjiao Yang  2 , Guowei Yu  3 , Qishan Wei  4
Affiliations
Meta-Analysis

Relationship between Helicobacter pylori infection and obesity in Chinese adults: A systematic review with meta-analysis

Xinlan Xu et al. PLoS One. .

Abstract

Background: Obesity is highly prevalent worldwide. More and more studies have been conducted on the relationship between H. pylori infection and obesity or overweight. But the relationship between them is controversial in the literatures and there is no comprehensive evidence for the correlation.

Aim: To evaluate the prevalence of H. pylori infection in Chinese adult subjects who received routine physical examinations and the relationship between H. pylori and obesity.

Methods: Literatures on H. pylori infection and obesity in Chinese population were searched in online databases. Relevant data were extracted independently by two researchers and meta-analysis was performed by using Review manager 5.3 software.

Results: 22 articles were selected with a total sample size of 178033. The pooled prevalence of H. pylori was 42% (95%CI: 37% to 47%) and mean difference of BMI between subjects with and without H. pylori infection was 0.94 (95%CI: -0.04 to 1.91). 9 eligible studies with 27111 subjects were used to calculated pooled OR value because they contained obesity groups. The OR value showed that H. pylori-positive subjects tended to be obese at a risk of 1.20 (95% CI: 1.13 to 1.28).

Conclusion: In China, obesity has association with H. pylori infection. H. pylori infection may be one of the risk factors for obesity.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Literature retrieval flow chart.
Fig 2
Fig 2. Forest plot of the odds ratio with corresponding 95% confidence intervals for H. pylori infection on obese subjects versus normal weight subjects.
Size of squares reflect the statistical weight of each study. Pooled OR value is indicated by an unshaded diamond.
Fig 3
Fig 3. Funnel plot of the association between H. pylori infection and obesity.
See this image and copyright information in PMC

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References

    1. World Health Organization. Body mass index classification [Internet]. [cited 2019 Oct 13]. https://www.who.int/gho/ncd/risk_factors/bmi_text/en/.
    1. Kanazawa M, Yoshiike N, Osaka T, Numba Y, Zimmet P, Inoue S. Criteria and classification of obesity in Japan and Asia-Oceania. Asia Pacific Journal of Clinical Nutrition 2003. January; 11(s8):S732–S737. 10.1046/j.1440-6047.11.s8.19.x - DOI - PubMed
    1. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2014; 384(9945):766–781. 10.1016/S0140-6736(14)60460-8 - DOI - PMC - PubMed
    1. Collaboration, Asia Pacific Cohort Studies. The burden of overweight and obesity in the Asia–Pacific region. Obesity Reviews An Official Journal of the International Association for the Study of Obesity 2007; 8:191–196. 10.1111/j.1467-789X.2006.00292.x . - DOI - PubMed
    1. Ramachandran A, Snehalatha C. Rising Burden of Obesity in Asia. Journal of Obesity 2010. August; 2010:1–8. 10.1155/2010/868573 . - DOI - PMC - PubMed

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