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. 2020 Feb 5;20(1):125-130.
doi: 10.17305/bjbms.2019.4352.

HPV infection screening using surface plasmon resonance in women from Kunming (Southwest China)

Yang Liu  1 , Yue Quan  2 , Changjun Xu  1 , Yajuan Huang  1 , Daizhu Li  1 , Qing Qing  1 , Chunyi Sun  1 , Honglin Zhou  3
Affiliations

HPV infection screening using surface plasmon resonance in women from Kunming (Southwest China)

Yang Liu et al. Bosn J Basic Med Sci. .

Abstract

No study examined the frequency of human papillomavirus (HPV) genotypes by surface plasmon resonance (SPR) in Southwest China. This was a cross-sectional survey (The Second Affiliated Hospital of Kunming Medical University, 10/2010 to 12/2011) in 150 patients who were hospitalized or volunteered for cervical cancer (CC) screening. A HPV typing kit was used to detect 24 types of HPV by the SPR technique. The HPV-positive rate was 34.8% in women with normal cytology and 92.9% in women with CC. The frequency of HPV16 increased from 9.4% for women with normal cytology to 28.9% for cervical intraepithelial neoplasia (CIN)1, 41.4% for CIN2, 54.1% for CIN3, and 71.4% for CC (p < 0.001). The frequency of HPV18 increased from 0% for women with normal cytology to 2.6% for CIN1, 3.4% for CIN2, 5.4% for CIN3, and 21.4% for CC (p = 0.03). HPV40 was only found in one patient with CC (p = 0.04). There was no relation between HPV genotype and women's age. In Kunming (Southwest China), the frequency of HPV infection was 74.0% among women who underwent CC screening. HPV16 and HPV18 were the two most frequent genotypes. SPR could be of value for the screening of HPV infection.

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Conflict of interest statement

Conflict of interest statement: The authors declare no conflict of interests

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