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Review
. 2019 Sep 10;9(9):470.
doi: 10.3390/biom9090470.

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Bolat Sultankulov  1 , Dmitriy Berillo  2   3 , Karina Sultankulova  4 , Tursonjan Tokay  5 , Arman Saparov  6
Affiliations
Review

Progress in the Development of Chitosan-Based Biomaterials for Tissue Engineering and Regenerative Medicine

Bolat Sultankulov et al. Biomolecules. .

Abstract

Over the last few decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with outstanding properties in line with excellent biodegradability, biocompatibility, and antimicrobial activity. Due to the presence of free amine groups in its backbone chain, chitosan could be further chemically modified to possess additional functional properties useful for the development of different biomaterials in regenerative medicine. In the current review, we will highlight the progress made in the development of chitosan-containing bioscaffolds, such as gels, sponges, films, and fibers, and their possible applications in tissue repair and regeneration, as well as the use of chitosan as a component for drug delivery applications.

Keywords: biomaterials; bone; cartilage; chitosan; regenerative medicine; tissue engineering.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chitin and chitosan structure.
Figure 2
Figure 2
Main properties of chitosan (CS) used for skin, bone, and cartilage regeneration.
See this image and copyright information in PMC

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