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Case Reports
. 2019 Aug 30;39(8):923-929.
doi: 10.12122/j.issn.1673-4254.2019.08.08.

[Primary intraosseous hematopoietic pseudotumor: clinicopathological analysis and 9-year follow-up of 3 cases]

[Article in Chinese]
Na Tang  1   2 , Suqi Deng  3 , Yongjian Deng  4   5
Affiliations
Case Reports

[Primary intraosseous hematopoietic pseudotumor: clinicopathological analysis and 9-year follow-up of 3 cases]

[Article in Chinese]
Na Tang et al. Nan Fang Yi Ke Da Xue Xue Bao. .

Abstract
in English, Chinese

We analyzed the clinicopathological data of 3 cases of primary intraosseous hematopoietic pseudotumor (IHPT), which had been previously misdiagnosed as malignancies or metastases both clinically and pathologically. Two of the patients received close follow-up for 132 and 100 months, and one patient was lost to follow-up, and the tumors were confirmed to be benign in all the 3 cases. IHPT is a rare benign intraosseous solid lesion consisting of tissues resembling normal hematopoietic tissue, and can be easily misdiagnosed as malignancy. Understanding the clinicopathological features and the outcomes of the disease can facilitate the clinical decisions on individualized diagnosis and therapeutic regimens.

本研究收集、分析3例骨内造血细胞假瘤的临床病理资料，初始临床和病理学诊断，都被误诊为恶性肿瘤/转移灶，其中2例分别随访了132月和100月，均证明为良性肿瘤（1例失访）。造血细胞假瘤由类似正常造血组织组成的骨内罕见的良性病变，易被误诊为恶性造血细胞肿瘤，熟知其临床病理特征与转归过程，能够建立正确的个体化诊治方案。

Keywords: extramedullary hematopoiesis; hematopoietic cells hyperplasia; intraosseous hematopoietic pseudotumor.

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Figures

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1
病例1的影像学资料 Imaging findings in Case 1. (A) MRI showed an oval mass in the marrow cavity of the left upper femur with partial osteolysis of the femoral central cortex. The mass was 4.5 cm×2.5 cm×2.6 cm. (B) Transversal image. (C) PET-CT examination at 2 months after the mass was removed. The images showed a slight uptake of 18F-fluoro-3'deoxy-L-thymidine (18F-FDG) in the bone marrow of the left upper femur, which suggested the healing at the primary site. No other abnormal uptake of 18F-FDG was found in other parts of the body
2
2
病例2的影像学资料 Imaging findings in Case 2. PET- CT showed the abnormal uptake of 18F-FDG in the lesion in the marrow cavity of the left upper femur (A) and the lower tibia (B). The density of the lesions was higher than that observed in normal bone marrow
3
3
病例3的影像学资料 Imaging findings in Case 3. CT showed an osteolytic mass of 9.6 cm×7.8 cm×6.4 cm at the left sacroiliac joint and projected into the peripheral soft tissues. Some bone fragments were found in the center of the tumor but without necrotic patches (A-C). Xray also showed the mass as in the doted circle (D)
4
4
病例1 Pathological examination of lesion in Case 1, A: Histopathological examination of the lesion showed a histological feature resembling normal bone marrow with scattered fat tissue (HE staining); B: Immunohistochemistry for CD45 showed myelolymphoid lineage cells; C: CD61 immunostaining showed megakaryocyte lineage cells. The dispersed cells were positive for CD3 (D) and CD20 (E). F: 3.1% of the cells (not including the endothelial cells) were CD34-positive
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