Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Sep 11;9(9):e028653.
doi: 10.1136/bmjopen-2018-028653.

Dose-response relationship between physical activity and mortality in people with non-communicable diseases: a study protocol for the systematic review and meta-analysis of cohort studies

Wolfgang Geidl  1 , Sabrina Schlesinger  2 , Eriselda Mino  3 , Lorena Miranda  3 , Anna Ryan  3 , Katja Bartsch  3 , Lukas Janz  3 , Klaus Pfeifer  3
Affiliations

Dose-response relationship between physical activity and mortality in people with non-communicable diseases: a study protocol for the systematic review and meta-analysis of cohort studies

Wolfgang Geidl et al. BMJ Open. .

Abstract

Introduction: This study protocol outlines our planned systematic review and dose-response meta-analysis of postdiagnosis physical activity and mortality in people with non-communicable diseases (NCDs).

Methods and analysis: This study is based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis for Protocols. A systematic literature search will be conducted in various databases-namely, PubMed, Scopus and Web of Science-by two researchers in order to identify prospective observational studies that investigate postdiagnosis physical activity or activity-related energy expenditure and mortality in individuals with NCDs. The target population is adults (≥18 years of age) with one of the following nine NCDs: low back pain, type 2 diabetes mellitus, osteoarthritis, depressive disorder, chronic obstructive pulmonary disease, breast cancer, lung cancer, stroke or ischaemic heart disease. We will focus on all-cause mortality as the primary outcome and investigate indication-specific mortality as the secondary outcome. For each study identified as a result of the literature search, we will conduct graphical dose-response analyses of mortality as a function of activity-related energy consumption. If more than two studies are available for one disease, we will perform linear and non-linear dose-response meta-analyses for said disease using random-effects models. We will investigate the heterogeneity of the studies and publication bias. To assess the risk of bias and the quality of the included studies, we will use the Risk Of Bias In Non-randomised Studies - of Interventions tool, which is a Cochrane tool.

Ethics and dissemination: This systematic review will be conducted in compliance with ethical precepts. As the systematic review is based on published studies, approval from an ethics committee is not required. The systematic review and meta-analysis will be published in a peer-reviewed journal.

Prospero registration number: CRD42018103357.

Keywords: exercise; meta-analysis; mortality; non-communicable diseases; physical activity; systematic review.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Similar articles

See all similar articles

Cited by

References

    1. World Health Organization Global recommendations on physical activity for health. Geneva, Switzerland: World Health Organization, 2010. - PubMed
    1. Warburton D, Bredin S. Health benefits of physical activity: a systematic review of current systematic reviews. Curr Opin Cardiol 2017;32:541–56. - PubMed
    1. Arem H, Moore SC, Patel A, et al. . Leisure time physical activity and mortality: a detailed pooled analysis of the dose-response relationship. JAMA Intern Med 2015;175:959–67. - PMC - PubMed
    1. Samitz G, Egger M, Zwahlen M. Domains of physical activity and all-cause mortality: systematic review and dose–response meta-analysis of cohort studies. Int J Epidemiol 2011;40:1382–400. 10.1093/ije/dyr112 - DOI - PubMed
    1. U.S. Department of Health and Human Services Physical activity guidelines for Americans. 2nd edition Washington, DC: U.S.: Department of Health and Human Services, 2018.