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Comment
. 2019 Aug:3:14.
doi: 10.21037/biotarget.2019.08.01. Epub 2019 Aug 23.

YAP-dependent metabolic remodeling in local lymph node boosts the function of cancer cells

Toshihide Kashihara  1 , Daniela Zablocki  1 , Junichi Sadoshima  1
Affiliations
Comment

YAP-dependent metabolic remodeling in local lymph node boosts the function of cancer cells

Toshihide Kashihara et al. Biotarget. 2019 Aug.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
The molecular mechanism by which YAP mediates metabolic remodeling and growth of metastatic cancer cells in local lymph nodes. The microenvironment in local lymph nodes, such as the availability of fatty acids, promotes YAP-induced activation of fatty acid oxidation, which in turn boosts growth and invasiveness in metastatic cancer cells. Increased production of bile acids in lymph node-metastatic cancer cells activates YAP through unknown mechanisms. YAP activates fatty acid oxidation through interaction with unknown transcription factors. Interventions to inhibit bile acid synthesis, YAP or fatty acid oxidation may attenuate metastasis of cancer cells. YAP, yes-associated protein.
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