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. 2020:2066:125-132.
doi: 10.1007/978-1-4939-9837-1_11.

Sperm-Mediated Genetic Modifications

Marialuisa Lavitrano  1 , Laura Farina  2 , Maria Grazia Cerrito  2 , Roberto Giovannoni  2
Affiliations

Sperm-Mediated Genetic Modifications

Marialuisa Lavitrano et al. Methods Mol Biol. 2020.

Abstract

The ability to introduce controlled modifications of the genome of animals represents an important tool for biomedical and veterinary research. Among transgenic techniques, we describe here the sperm-mediated gene transfer method that is based on the spontaneous ability of sperm cells to bind and internalize exogenous DNA and to carry it to the oocyte during fertilization, producing genetically modified animals.

Keywords: Mouse; SMGT; Spermatozoa; Transgenesis; Transgenic animals.

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