Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan;54(1):8-21.
doi: 10.1097/MCG.0000000000001267.

Celiac Disease: Extraintestinal Manifestations and Associated Conditions

Amelie Therrien  1   2 , Ciaran P Kelly  1   2 , Jocelyn A Silvester  2   3   4
Affiliations
Review

Celiac Disease: Extraintestinal Manifestations and Associated Conditions

Amelie Therrien et al. J Clin Gastroenterol. 2020 Jan.

Abstract

Celiac disease is a common form of enteropathy with frequent extraintestinal manifestations (EIM). Misrecognition of these presentations may lead to significant delays in diagnosis. Any organ may be involved, either through an immune/inflammatory phenomenon, or nutritional deficiencies. Some EIM, such as gluten ataxia, may be irreversible if left untreated, but most will improve with a gluten-free diet. Knowledge of the various EIM, as well as the associated conditions which do not improve on a gluten-free diet, will avoid delays in the diagnosis and management of celiac disease and associated manifestations.

PubMed Disclaimer

Conflict of interest statement

Disclosures: JAS has received consulting fees from Takeda Pharmaceuticals International Co, and research support from Cour Pharmaceuticals, Biomedal SL and Glutenostics LLC. CPK has acted as a scientific advisor to companies attempting to develop new diagnostic and management approaches for Celiac disease including Cour Pharmaceuticals, Glutenostics, Innovate, ImmunogenX and Takeda Pharmaceuticals. He also acts as Principal Investigator on research grants on Celiac disease supported by Aptalis and Takeda Pharmaceuticals International Co. AT has no conflict to disclose.

Figures

Figure 1:
Figure 1:
Main Extraintestinal Manifestations Associated with Celiac Disease
See this image and copyright information in PMC

References

    1. Singh P, Arora A, Strand TA, et al. Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 2018. - PubMed
    1. Dieterich W, Ehnis T, Bauer M, et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 1997;3:797–801. - PubMed
    1. Rampertab SD, Pooran N, Brar P, et al. Trends in the presentation of celiac disease. Am J Med 2006;119:355 e9–14. - PubMed
    1. Jericho H, Sansotta N, Guandalini S. Extraintestinal Manifestations of Celiac Disease: Effectiveness of the Gluten-Free Diet. J Pediatr Gastroenterol Nutr 2017;65:75–9. - PubMed
    1. Paez MA, Gramelspacher AM, Sinacore J, et al. Delay in Diagnosis of Celiac Disease in Patients Without Gastrointestinal Complaints. Am J Med 2017;130:1318–23. - PubMed

Publication types

MeSH terms