[Zollinger-Ellison syndrome]

Abstract

Three patients with Zollinger-Ellison syndrome are reported. In the first one, on the base of fibroduodenoscopy, an ulceriform cancer was found in the region of Vater's papilla in duodenum, with a penetration to pancreas and the elimination of gastrinoma (duodenectomy with right-side pancreas resection) led to the clinical healing, normalization of stomach secretion and the rest of the laboratory tests. Six years after the operation, the patient had no complaints and is with well preserved capacity for work. A gastrinoma, hazel-nut size, localized in the distal end of Wirsung's canal was concerned in the other two patients, that led to multiple recidivation and complications (hemorrhages and fistulas) of the duodenal peptic ulcer. One of the patients, due to the complications, underwent 7 resections and the other -- 3 but in neither of the two a radical operative intervention was performed (gastrinoma elimination or total gastrectomy) due to which one of them died four years and the other -- 8 years after the first operation and the onset of the clinical manifestations. Only the present radical operation treatment could lead to permanent results.