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Review
. 2019 Dec:200:105168.
doi: 10.1016/j.actatropica.2019.105168. Epub 2019 Sep 9.

Immunity and vaccine development efforts against Trypanosoma cruzi

Lizette E Rios  1 , Juan Carlos Vázquez-Chagoyán  2 , Antonio Ortega Pacheco  3 , M Paola Zago  4 , Nisha J Garg  5
Affiliations
Review

Immunity and vaccine development efforts against Trypanosoma cruzi

Lizette E Rios et al. Acta Trop. 2019 Dec.

Abstract

Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a critical lack of methods for prevention of infection or treatment of acute infection and chronic disease. Studies in experimental models have suggested that the protective immunity against T. cruzi infection requires the elicitation of Th1 cytokines, lytic antibodies and the concerted activities of macrophages, T helper cells, and cytotoxic T lymphocytes (CTLs). In this review, we summarize the research efforts in vaccine development to date and the challenges faced in achieving an efficient prophylactic or therapeutic vaccine against human CD.

Keywords: Adjuvants; Chagas; Immunity; Prophylactic; Therapeutic; Vaccine.

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References

    1. Abrahamsohn IA, Coffman RL, 1996. Trypanosoma cruzi: IL-10, TNF-alpha, IFN-gamma, and IL-12 regulate innate and acquired immunity to infection. Exp. Parasitol. 84, 231–244. - PubMed
    1. Acevedo GR, Girard MC, Gómez KA, 2018. The unsolved jigsaw puzzle of the immune response in Chagas disease. Front. Immunol. 9, 1929. - PMC - PubMed
    1. Acosta-Serrano A, Almeida IC, Freitas-Junior LH, Yoshida N, Schenkman S, 2001. The mucin-like glycoprotein super-family of Trypanosoma cruzi: structure and biological roles. Mol. Biochem. Parasitol. 114, 143–150. - PubMed
    1. Aliberti JC, Souto JT, Marino AP, Lannes-Vieira J, Teixeira MM, Farber J, Gazzinelli RT, Silva JS, 2001. Modulation of chemokine production and inflammatory responses in interferon-gamma- and tumor necrosis factor-R1-deficient mice during Trypanosoma cruzi infection. Am. J. Pathol. 158, 1433–1440. - PMC - PubMed
    1. Almeida IC, Camargo MM, Procópio DO, Silva LS, Mehlert A, Travassos LR, Gazzinelli RT, Ferguson MA, 2000. Highly purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents. EMBO J. 1476–1485. - PMC - PubMed

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