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Comment
. 2019 Sep 11;26(3):307-308.
doi: 10.1016/j.chom.2019.08.015.

Fueling the Optimal Microbiome: Interventions for Severe Acute Malnutrition

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Free article
Comment

Fueling the Optimal Microbiome: Interventions for Severe Acute Malnutrition

Josef Neu. Cell Host Microbe. .
Free article

Abstract

Studies of the intestinal microbial environment largely focus on microbial taxonomy, without clarifying their health benefits. Two recent studies (Raman et al. and Gehrig et al.) classify microbial environments into "ecogroups" that provide insight into their metabolic and/or nutritional pathways and how this can be used for interventions in malnourished children.

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  • Effects of microbiota-directed foods in gnotobiotic animals and undernourished children.
    Gehrig JL, Venkatesh S, Chang HW, Hibberd MC, Kung VL, Cheng J, Chen RY, Subramanian S, Cowardin CA, Meier MF, O'Donnell D, Talcott M, Spears LD, Semenkovich CF, Henrissat B, Giannone RJ, Hettich RL, Ilkayeva O, Muehlbauer M, Newgard CB, Sawyer C, Head RD, Rodionov DA, Arzamasov AA, Leyn SA, Osterman AL, Hossain MI, Islam M, Choudhury N, Sarker SA, Huq S, Mahmud I, Mostafa I, Mahfuz M, Barratt MJ, Ahmed T, Gordon JI. Gehrig JL, et al. Science. 2019 Jul 12;365(6449):eaau4732. doi: 10.1126/science.aau4732. Science. 2019. PMID: 31296738 Free PMC article. Clinical Trial.
  • A sparse covarying unit that describes healthy and impaired human gut microbiota development.
    Raman AS, Gehrig JL, Venkatesh S, Chang HW, Hibberd MC, Subramanian S, Kang G, Bessong PO, Lima AAM, Kosek MN, Petri WA Jr, Rodionov DA, Arzamasov AA, Leyn SA, Osterman AL, Huq S, Mostafa I, Islam M, Mahfuz M, Haque R, Ahmed T, Barratt MJ, Gordon JI. Raman AS, et al. Science. 2019 Jul 12;365(6449):eaau4735. doi: 10.1126/science.aau4735. Science. 2019. PMID: 31296739 Free PMC article.

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