Fusobacterium nucleatum bacteremia with pneumopathy in a patient receiving eculizumab: A case report

Abstract

Fusobacterium nucleatum is a common oral commensal bacterium capable of severe invasive infections. We report a case of a diffuse bilateral pneumopathy with F. nucleatum-positive blood culture successfully treated by common antibiotics in a patient receiving eculizumab for a drug-induced thrombotic microangiopathy (TMA). It is the first described case of a severe F. nucleatum-associated infection in a patient undergoing terminal complement inhibitor therapy. We suggest providing preventive dental care before eculizumab initiation.

Keywords: Eculizumab; Fusobacterium nucleatum; Periodontitis; Pneumopathy.