Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Sep 17;74(11):1491-1493.
doi: 10.1016/j.jacc.2019.07.034.

Predicting Arrhythmia Risk in Dilated Cardiomyopathy Using Genetic Mutation Status

Elizabeth M McNally  1 , Ansel Philip Amaral  2
Affiliations
Editorial

Predicting Arrhythmia Risk in Dilated Cardiomyopathy Using Genetic Mutation Status

Elizabeth M McNally et al. J Am Coll Cardiol. .
No abstract available

Keywords: desmosomal mutations; dilated cardiomyopathy; genotype-phenotype correlation; prognosis.

PubMed Disclaimer

Conflict of interest statement

COI: EMM serves as a consultant to Invitae, Tenaya Therapeutics, Exonics, and is the founder of Ikaika Therapeutics. These activities are unrelated to the content of this work. APA has no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
DCM genes evaluated by Gigli et al. in a DCM cohort. Genes in the center column are also linked to ARVC. Genes with heightened ventricular arrhythmia risk in the setting of DCM are shown in orange.
See this image and copyright information in PMC

Comment on

  • Genetic Risk of Arrhythmic Phenotypes in Patients With Dilated Cardiomyopathy.
    Gigli M, Merlo M, Graw SL, Barbati G, Rowland TJ, Slavov DB, Stolfo D, Haywood ME, Dal Ferro M, Altinier A, Ramani F, Brun F, Cocciolo A, Puggia I, Morea G, McKenna WJ, La Rosa FG, Taylor MRG, Sinagra G, Mestroni L. Gigli M, et al. J Am Coll Cardiol. 2019 Sep 17;74(11):1480-1490. doi: 10.1016/j.jacc.2019.06.072. J Am Coll Cardiol. 2019. PMID: 31514951 Free PMC article.

References

    1. Wilcox JE, Hershberger RE. Genetic cardiomyopathies. Curr Opin Cardiol 2018;33:354–362. - PubMed
    1. Elliott PM, Anastasakis A, Asimaki A et al. Definition and treatment of arrhythmogenic cardiomyopathy: an updated expert panel report. Eur J Heart Fail 2019. - PMC - PubMed
    1. McNally EM, Mestroni L. Dilated Cardiomyopathy: Genetic Determinants and Mechanisms. Circ Res 2017;121:731–748. - PMC - PubMed
    1. Gigli M, Merlo M, Graw S et al. Genetic Risks for Arrhythmia Phenotypes in Dilated Cardiomyopathy. J Am Coll Cardiol 2019;in press. - PMC - PubMed
    1. Choi SH, Weng LC, Roselli C et al. Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation. Jama 2018;320:2354–2364. - PMC - PubMed