EXERCISE-ASSOCIATED HYPONATREMIA
Abstract
Exercise-associated hyponatremia (EAH) is defined by an acute fall in the serum or plasma sodium concentration to below 135 mmol/L that occurs during or up to 24 hours after prolonged physical activity. EAH has been reported in nearly every form of endurance activity and has a common pathogenic feature of excessive water intake which is usually coupled with elevated vasopressin levels. Symptomatic EAH is uncommon but can be a cause of mortality in otherwise healthy adults and children. Rapid recognition and appropriate treatment with hypertonic saline are essential to maximizing outcomes and preventing death.
Conflict of interest statement
Potential Conflicts of Interest: None disclosed.
Similar articles
-
Exercise-associated hyponatremia.Semin Nephrol. 2009 May;29(3):271-81. doi: 10.1016/j.semnephrol.2009.03.001. Semin Nephrol. 2009. PMID: 19523574 Review.
-
Exercise-associated hyponatremia: role of cytokines.Am J Med. 2006 Jul;119(7 Suppl 1):S74-8. doi: 10.1016/j.amjmed.2006.05.012. Am J Med. 2006. PMID: 16843089 Review.
-
Exercise-Associated Hyponatremia.Front Horm Res. 2019;52:178-189. doi: 10.1159/000493247. Epub 2019 Jan 15. Front Horm Res. 2019. PMID: 32097926 Review.
-
Practical management of exercise-associated hyponatremic encephalopathy: the sodium paradox of non-osmotic vasopressin secretion.Clin J Sport Med. 2008 Jul;18(4):350-4. doi: 10.1097/JSM.0b013e3181802c6d. Clin J Sport Med. 2008. PMID: 18614887
-
Wilderness Medical Society practice guidelines for treatment of exercise-associated hyponatremia.Wilderness Environ Med. 2013 Sep;24(3):228-40. doi: 10.1016/j.wem.2013.01.011. Epub 2013 Apr 13. Wilderness Environ Med. 2013. PMID: 23590928
Cited by
-
Exercise-Associated Hyponatremia in Marathon Runners.J Clin Med. 2022 Nov 16;11(22):6775. doi: 10.3390/jcm11226775. J Clin Med. 2022. PMID: 36431252 Free PMC article. Review.
-
Thalamic Neuron Resilience during Osmotic Demyelination Syndrome (ODS) Is Revealed by Primary Cilium Outgrowth and ADP-ribosylation factor-like protein 13B Labeling in Axon Initial Segment.Int J Mol Sci. 2023 Nov 17;24(22):16448. doi: 10.3390/ijms242216448. Int J Mol Sci. 2023. PMID: 38003639 Free PMC article.
-
Exertional hyponatremia among active component members of the U.S. Armed Forces, 2009-2024.MSMR. 2025 Jun 20;32(6):17-22. MSMR. 2025. PMID: 40591377 Free PMC article.
-
Exertional hyponatremia among active component members of the U.S. Armed Forces, 2008-2023.MSMR. 2024 Apr 20;31(4):15-19. MSMR. 2024. PMID: 38722575 Free PMC article.
-
Changes in Factors Regulating Serum Sodium Homeostasis During Two Ultra-Endurance Mountain Races of Different Distances: 69km vs. 121km.Front Physiol. 2021 Nov 18;12:764694. doi: 10.3389/fphys.2021.764694. eCollection 2021. Front Physiol. 2021. PMID: 34867470 Free PMC article.
References
-
- Noakes TD, Goodwin N, Rayner BL, et al. Water intoxication: a possible complication during endurance exercise. Med Sci Sports Exerc. 1985;17:370–5. - PubMed
-
- Montain SJ, Sawka MN, Wenger CB. Hyponatremia associated with exercise: risk factors and pathogenesis. Exerc Sport Sci Rev. 2001;29:113–7. - PubMed
-
- Speedy DB, Noakes TD, Schneider C. Exercise-associated hyponatremia: a review. Emerg Med (Fremantle) 2001;13:17–27. - PubMed
-
- Rosner MH, Kirven J. Exercise-associated hyponatremia. Clin J Am Soc Nephrol. 2007;2:151–61. - PubMed
-
- Rosner MH. Exercise-associated hyponatremia. Semin Nephrol. 2009;29:271–81. - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical