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Review
. 2019 Sep;33(9):388-398.
doi: 10.1089/apc.2019.0095.

Improving the Youth HIV Prevention and Care Cascades: Innovative Designs in the Adolescent Trials Network for HIV/AIDS Interventions

Sylvie Naar  1 , Michael G Hudgens  2 , Ron Brookmeyer  3 , April Idalski Carcone  4 , Jason Chapman  5 , Shrabanti Chowdhury  6 , Andrea Ciaranello  7 , W Scott Comulada  3 , Samiran Ghosh  4 , Keith J Horvath  8 , LaDrea Ingram  9 , Sara LeGrand  10 , Cathy J Reback  11 , Kit Simpson  12 , Bonita Stanton  13 , Tyrel Starks  14 , Dallas Swendeman  3
Affiliations
Review

Improving the Youth HIV Prevention and Care Cascades: Innovative Designs in the Adolescent Trials Network for HIV/AIDS Interventions

Sylvie Naar et al. AIDS Patient Care STDS. 2019 Sep.

Abstract

Dramatic decreases in HIV transmission are achievable with currently available biomedical and behavioral interventions, including antiretroviral therapy and pre-exposure prophylaxis. However, such decreases have not yet been realized among adolescents and young adults. The Adolescent Medicine Trials Network (ATN) for HIV/AIDS interventions is dedicated to research addressing the needs of youth at high risk for HIV acquisition as well as youth living with HIV. This article provides an overview of an array of efficient and effective designs across the translational spectrum that are utilized within the ATN. These designs maximize methodological rigor and real-world applicability of findings while minimizing resource use. Implementation science and cost-effectiveness methods are included. Utilizing protocol examples, we demonstrate the feasibility of such designs to balance rigor and relevance to shorten the science-to-practice gap and improve the youth HIV prevention and care continua.

Keywords: HIV; adolescent; behavioral; methods.

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Conflict of interest statement

No competing financial interests exist.

Figures

<b>FIG. 1.</b>
FIG. 1.
Translational spectrum of behavioral research.
<b>FIG. 2.</b>
FIG. 2.
Example of user-centered design in ATN 142. ATN, Adolescent Medicine Trials Network.
<b>FIG. 3.</b>
FIG. 3.
ATN 148 schematic of increasing levels of care and decision points around VL for stepped care arm. ATN, Adolescent Medicine Trials Network; VL, viral load.
<b>FIG. 4.</b>
FIG. 4.
New translational behavioral research model to guide adolescent HIV research agenda.
See this image and copyright information in PMC

References

    1. Cohen MS, Chen YQ, McCauley M, et al. . Antiretroviral therapy for the prevention of HIV-1 transmission. N Engl J Med 2016;375:830–839 - PMC - PubMed
    1. Fonner VA, Dalglish SL, Kennedy CE, et al. . Effectiveness and safety of oral HIV preexposure prophylaxis for all populations. AIDS 2016;30:1973–1983 - PMC - PubMed
    1. Zanoni BC, Mayer KH. The adolescent and young adult HIV cascade of care in the United States: Exaggerated health disparities. AIDS Patient Care STDS 2014;28:128–135 - PMC - PubMed
    1. Parsons JT, Rendina HJ, Lassiter JM, Whitfield TH, Starks TJ, Grov C. Uptake of HIV pre-exposure prophylaxis (PrEP) in a national cohort of gay and bisexual men in the United States. J Acquir Immune Defic Syndr 2017;74:285–292 - PMC - PubMed
    1. Freese TE, Padwa H, Oeser BT, Rutkowski BA, Schulte MT. Real-world strategies to engage and retain racial-ethnic minority young men who have sex with men in HIV prevention services. AIDS Patient Care STDS 2017;31:275–281 - PubMed

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