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. 2019 Sep 6;51(10):1041-1048.
doi: 10.1093/abbs/gmz090.

Functional improvement and maturation of human cardiomyocytes derived from human pluripotent stem cells by barbaloin preconditioning

Hui Yang  1   2 , Weiyi Zhong  3 , Mohammad Rafi Hamidi  1 , Gaojun Zhou  4 , Chen Liu  1
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Free article

Functional improvement and maturation of human cardiomyocytes derived from human pluripotent stem cells by barbaloin preconditioning

Hui Yang et al. Acta Biochim Biophys Sin (Shanghai). .
Free article

Abstract

The development of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is a significant advancement in our ability to obtain cardiomyocytes in vitro for regenerative therapies and drug discovery. However, hPSC-CMs obtained via existing protocols usually exhibit a markedly immature phenotype, compared with adult cardiomyocytes, thereby limiting their application. Here we report that barbaloin preconditioning dramatically improves the morphology, structure-related cardiac gene expression, calcium handling, and electrophysiological properties of hPSC-CMs, which means that barbaloin may have the potential to induce the maturation of hPSC-CMs, providing a novel strategy to generate more adult-like cardiomyocytes and promoting the application of hPSC-CMs in regenerative medicine, drug development, and disease modeling.

Keywords: barbaloin; cardiomyocyte; maturation; pluripotent stem cell.

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