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Review
. 2019 Sep 6;12(9):dmm040360.
doi: 10.1242/dmm.040360.

Modeling hematopoietic disorders in zebrafish

Martina Konantz  1 , Christoph Schürch  2 , Pauline Hanns  2 , Joëlle S Müller  2 , Loïc Sauteur  2 , Claudia Lengerke  2   3
Affiliations
Review

Modeling hematopoietic disorders in zebrafish

Martina Konantz et al. Dis Model Mech. .

Abstract

Zebrafish offer a powerful vertebrate model for studies of development and disease. The major advantages of this model include the possibilities of conducting reverse and forward genetic screens and of observing cellular processes by in vivo imaging of single cells. Moreover, pathways regulating blood development are highly conserved between zebrafish and mammals, and several discoveries made in fish were later translated to murine and human models. This review and accompanying poster provide an overview of zebrafish hematopoiesis and discuss the existing zebrafish models of blood disorders, such as myeloid and lymphoid malignancies, bone marrow failure syndromes and immunodeficiencies, with a focus on how these models were generated and how they can be applied for translational research.

Keywords: Blood disorders; Bone marrow failure syndrome; Disease models; Hematopoiesis; Immunodeficiency; Leukemia.

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Conflict of interest statement

Competing interestsThe authors declare no competing or financial interests.

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