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. 1988 Nov-Dec;40(6):691-5.

MAO activity, serotonin metabolism and aggregation of platelets from migraine patients. A preliminary study

K Kovács  1 , L Tóthfalusi, F Hermán, K Magyar
Affiliations
  • PMID: 3152004

MAO activity, serotonin metabolism and aggregation of platelets from migraine patients. A preliminary study

K Kovács et al. Pol J Pharmacol Pharm. 1988 Nov-Dec.

Abstract

Platelets of migraine patients showed abnormal behavior such as hyperaggregability and reduced monoamine oxidase activity (MAO). We measured the MAO activity, serotonin (5-HT) content and release, adenosine diphosphate (ADP)-induced aggregation, and the prostacyclin (PGI2) antiaggregatory effect using the same sample of platelets from migraine patients to find out if these characteristics are intercorrelated. A significant correlation between MAO activity and sensitivity to PGI2 was found.

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