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Review
. 2019:1167:1-14.
doi: 10.1007/978-3-030-23629-8_1.

Drosophila Model in Cancer: An Introduction

Deeptiman Chatterjee  1 , Wu-Min Deng  2
Affiliations
Review

Drosophila Model in Cancer: An Introduction

Deeptiman Chatterjee et al. Adv Exp Med Biol. 2019.

Abstract

Cancer is a cumulative manifestation of several complicated disease states that affect multiple organs. Over the last few decades, the fruit fly Drosophila melanogaster, has become a successful model for studying human cancers. The genetic simplicity and vast arsenal of genetic tools available in Drosophila provides a unique opportunity to address questions regarding cancer initiation and progression that would be extremely challenging in other model systems. In this chapter we provide a historical overview of Drosophila as a model organism for cancer research, summarize the multitude of genetic tools available, offer a brief comparison between different model organisms and cell culture platforms used in cancer studies and briefly discuss some of the latest models and concepts in recent Drosophila cancer research.

Keywords: Animal models; Apoptosis induced proliferation; Cachexia; Cancer; Cell competition; Drosophila; Drug discovery; Genetic tools; Tumor hotspots; Tumorigenesis.

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