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Randomized Controlled Trial
. 2019 Nov:217:101-111.
doi: 10.1016/j.ahj.2019.08.008. Epub 2019 Aug 15.

Comparison of the Cardiovascular Benefits of Resistance, Aerobic, and Combined Exercise (CardioRACE): Rationale, design, and methods

Angelique G Brellenthin  1 , Lorraine M Lanningham-Foster  2 , Marian L Kohut  1 , Yehua Li  3 , Timothy S Church  4 , Steven N Blair  5 , Duck-Chul Lee  6
Affiliations
Randomized Controlled Trial

Comparison of the Cardiovascular Benefits of Resistance, Aerobic, and Combined Exercise (CardioRACE): Rationale, design, and methods

Angelique G Brellenthin et al. Am Heart J. 2019 Nov.

Abstract

Background: The benefits of aerobic exercise (AE) for cardiovascular disease (CVD) have been well documented. Resistance exercise (RE) has been traditionally examined for its effects on bone density, physical function, or metabolic health, yet few data exist regarding the benefits of RE, independent of and combined with AE, for CVD prevention. This randomized controlled trial, "Comparison of the Cardiovascular Benefits of Resistance, Aerobic, and Combined Exercise (CardioRACE)," is designed to determine the relative benefits of RE, AE, or combined RE plus AE training on CVD risk factors.

Methods: Participants are 406 inactive men and women (35-70 years) with a body mass index of 25-40 kg/m2 and blood pressure (BP) of 120-139/80-89 mm Hg without taking antihypertensive medications. Participants are randomly assigned to RE only, AE only, combined RE and AE (CE), or a no exercise control group. Participants perform supervised exercise at 50%-80% of their relative maximum intensity for both AE and RE, 3 times a week for 60 minutes per session, for 1 year (all 3 groups are time matched).

Results: The primary outcome is a composite z score including resting BP, low-density lipoprotein cholesterol (LDL-C), fasting glucose, and percent body fat, which is assessed at baseline, 6 months, and 12 months. Diet and outside physical activity are measured throughout the intervention for 1 year.

Conclusion: CardioRACE (ClinicalTrials.govNCT03069092) will fill an important knowledge gap regarding the effects of RE, alone or in addition to the well-documented effects of AE. CardioRACE will help generate more comprehensive and synergistic clinical and public health strategies to prevent CVD.

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Figures

Figure 1:
Figure 1:. Participant flow from initial screening to randomization
Abbreviations: BMI, body mass index; BP, blood pressure; RE, resistance exercise training only; AE, aerobic exercise training only; CE, combined aerobic and resistance exercise training; CON, no-exercise control group.
Figure 2:
Figure 2:
Mechanistic pathway between resistance, aerobic, or combined exercise training and cardiovascular disease (CVD)
See this image and copyright information in PMC

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