Comment
doi: 10.1016/j.ccell.2019.08.010.
Colon Cancer: Epithelial Notch Signaling Recruits Neutrophils to Drive Metastasis
Affiliations
- PMID: 31526756
- DOI: 10.1016/j.ccell.2019.08.010
Item in Clipboard
Comment
Colon Cancer: Epithelial Notch Signaling Recruits Neutrophils to Drive Metastasis
Cancer Cell.
.
Free article
Abstract
In this issue of Cancer Cell, Jackstadt et al. report that pathological Notch signaling in colorectal cancer (CRC) cells can initiate a neutrophil-dependent, TGF-β-mediated cascade that leads to metastatic disease. Inhibition of this pathway with clinically relevant compounds blocks metastatic spread in a developed murine model of CRC.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
-
Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.Cancer Cell. 2019 Sep 16;36(3):319-336.e7. doi: 10.1016/j.ccell.2019.08.003. Cancer Cell. 2019. PMID: 31526760 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
