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. 2019 Oct;121(8):629-630.
doi: 10.1038/s41416-019-0570-y. Epub 2019 Sep 17.

Are we over-treating with checkpoint inhibitors?

Sarah Danson  1 , Jane Hook  2 , Helen Marshall  2 , Alexandra Smith  2 , Sue Bell  2 , Simon Rodwell  3 , Pippa Corrie  4
Affiliations

Are we over-treating with checkpoint inhibitors?

Sarah Danson et al. Br J Cancer. 2019 Oct.

Abstract

Anti-PD-1 antibodies offer potentially life-saving treatment for some cancer patients, but their chronic administration generates high and ever-increasing costs. Despite licensing for long-term use, optimal treatment duration is unknown. We challenge the need for long-term treatment duration, using evidence from melanoma research, both published and in process.

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Conflict of interest statement

The authors are co-applicants on the DANTE trial. S.D. has received conference and travel support from MSD, Pierre Fabre and BMS; and sat on advisory boards for MSD and BMS. P.C. has received speaker fees and sat on advisory boards for MSD, BMS, Novartis and Pierre Fabre. S.R. is CEO of the charity Melanoma Focus. The remaining authors declare no competing interests.

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