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. 2019 Jun 24;16(5):451-453.
doi: 10.1016/j.jor.2019.06.023. eCollection 2019 Sep-Oct.

A rare case of melorheostosis of the hand in a pediatric patient

Rolanda A Willacy  1   2   3 , James A Clemmons  1 , Ore Oyetan  1 , Ibrahim M Khaleel  1 , Christopher G Salib  2 , Robert H Wilson  1   2   3
Affiliations

A rare case of melorheostosis of the hand in a pediatric patient

Rolanda A Willacy et al. J Orthop. .

Erratum in

Abstract

Melorheostosis, a rare mesenchymal dysplasia of bone, generally affects about 0.001% of people globally with about 400 cases total being reported. Melorheostosis of the hand, especially in the pediatric population, has been seldom reported. Previous studies have investigated potential genetic mutations associated with melorheostosis however, questions still remain regarding effective treatment options for this disease. This case report describes a unique case of pediatric melorheostosis of the hand and further clarifies current theories on melorheostosis with regards to pathogenesis, best treatment practices, and future research.

Keywords: Candle wax appearance; Contractures; Hyperostosis; LEMD3 gene; MAPK21 oncogene; Melorheostosis; Mesenchymal dysplasia.

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Figures

Fig. 1
Fig. 1
A, B. Initial radiographs of a skeletally immature right hand with (A) anteriorposterior and (B) oblique views demonstrating mild rotation of the index finger and slight radial deviation of the long finger.
Fig. 2
Fig. 2
A, B, C. Radiographs of a skeletally immature right hand with (A) anteroposterior, (B) oblique, and (C) lateral views demonstrating melorheostosis of cortical borders of the 2nd and 3rd metacarpals, as well as involvement of the proximal, middle, and distal phalanges of the 2nd and 3rd digits.
See this image and copyright information in PMC

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