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. 2019 Jun 20;6(5):e1618178.
doi: 10.1080/23723556.2019.1618178. eCollection 2019.

Finding MYCure

Marie-Eve Beaulieu  1 , Laura Soucek  1   2   3   4
Affiliations

Finding MYCure

Marie-Eve Beaulieu et al. Mol Cell Oncol. .

Abstract

Inhibiting the nuclear protein MYC involved in the majority of human cancers has long been considered an impossible mission and several technical challenges have discouraged the development of MYC inhibitory strategies. Nevertheless, in our recent publication in Science Translational Medicine "Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy", we demonstrate for the first time the feasibility of pharmacological MYC inhibition in vitro and in vivo using an Omomyc-based mini-protein.

Keywords: MYC; NSCLC; OMOMYC; mini-protein; peptide therapeutic.

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Figures

Figure 1.
Figure 1.
Proof of concept of the pharmacological application of the Omomyc mini-protein as a therapeutic for the treatment of Non-Small-Cell Lung Cancer (NSCLC). The Omomyc mini-protein was administered intranasally (on the left) in a mouse model of KRAS-driven NSCLC and intravenously (on the right) in a xenograft model of human NSCLC H1975 cells, where it was either used alone or in combination with paclitaxel (PTX), considered in this case as standard of care (SOC).
See this image and copyright information in PMC

References

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