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. 2019 Jun 24;6(5):e1632686.
doi: 10.1080/23723556.2019.1632686. eCollection 2019.

Hepatocytes prepare the soil for liver metastasis

Jae W Lee  1   2 , Gregory L Beatty  1   2
Affiliations

Hepatocytes prepare the soil for liver metastasis

Jae W Lee et al. Mol Cell Oncol. .

Abstract

The liver is the most common organ site of cancer metastasis. Molecular determinants of this organotropism, though, are poorly understood. We recently showed that hepatocytes regulate the formation of a "pro-metastatic" niche in the liver via their release of serum amyloid proteins.

Keywords: Metastasis; hepatocytes; liver; pancreatic cancer; therapy.

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Figures

Figure 1.
Figure 1.
Formation of a pro-metastatic niche in the liver and therapeutic strategies. Early during pancreatic tumor development, non-malignant cells that reside within primary tumors release interleukin 6 (IL-6) into the circulation. IL-6 then activates signal transducer and activator of transcription 3 (STAT3) signaling in hepatocytes, which in turn produce serum amyloid A proteins (SAA) that orchestrate the formation of a pro-metastatic niche in the liver. This process presents multiple points of therapeutic intervention (shown in red). IL-6R, IL-6 receptor.
See this image and copyright information in PMC

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