Managing atopic dermatitis with systemic therapies in adults and adolescents: An Australian/New Zealand narrative

Marius Rademaker¹, Karen Agnew^{2

3}, Megan Andrews⁴, Christopher Baker^{5

6}, Peter Foley^{5

6}, Kurt Gebauer^{7

8}, Monisha Gupta^{9

10

11}, Diana M Rubel^{12

13}, Colin Somerville¹⁴, John Sullivan¹⁵, Li-Chuen Wong¹⁶

Affiliations

¹ Waikato Clinical Campus, University of Auckland's Faculty of Medical and Health Sciences, Hamilton, New Zealand.
² Dermatology Department, Greenlane Clinical Centre, Auckland, New Zealand.
³ Starship Children's Hospital, Auckland, New Zealand.
⁴ Woolloongabba, Queensland, Australia.
⁵ St Vincent's Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
⁶ Skin & Cancer Foundation Inc., Carlton, Victoria, Australia.
⁷ University of Western Australia, Perth, Western Australia, Australia.
⁸ Probity Medical Research, Freemantle, Western Australia, Australia.
⁹ Department of Dermatology, Liverpool Hospital, Sydney, New South Wales, Australia.
¹⁰ The Skin Hospital, Darlinghurst, New South Wales, Australia.
¹¹ University of New South Wales, Sydney, New South Wales, Australia.
¹² Woden Dermatology, Phillip, Australian Capital Territory, Australia.
¹³ Australian National University, Canberra, Australian Capital Territory, Australia.
¹⁴ The Allergy West Clinic - Immunology, Perth, Western Australia, Australia.
¹⁵ Kingsway Dermatology, Miranda, New South Wales, Australia.
¹⁶ The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

PMID: 31529493
DOI: 10.1111/ajd.13141

Review

Managing atopic dermatitis with systemic therapies in adults and adolescents: An Australian/New Zealand narrative

Marius Rademaker et al. Australas J Dermatol. 2020 Feb.

. 2020 Feb;61(1):9-22.

doi: 10.1111/ajd.13141. Epub 2019 Sep 16.

Authors

Affiliations

¹ Waikato Clinical Campus, University of Auckland's Faculty of Medical and Health Sciences, Hamilton, New Zealand.
² Dermatology Department, Greenlane Clinical Centre, Auckland, New Zealand.
³ Starship Children's Hospital, Auckland, New Zealand.
⁴ Woolloongabba, Queensland, Australia.
⁵ St Vincent's Hospital, The University of Melbourne, Melbourne, Victoria, Australia.
⁶ Skin & Cancer Foundation Inc., Carlton, Victoria, Australia.
⁷ University of Western Australia, Perth, Western Australia, Australia.
⁸ Probity Medical Research, Freemantle, Western Australia, Australia.
⁹ Department of Dermatology, Liverpool Hospital, Sydney, New South Wales, Australia.
¹⁰ The Skin Hospital, Darlinghurst, New South Wales, Australia.
¹¹ University of New South Wales, Sydney, New South Wales, Australia.
¹² Woden Dermatology, Phillip, Australian Capital Territory, Australia.
¹³ Australian National University, Canberra, Australian Capital Territory, Australia.
¹⁴ The Allergy West Clinic - Immunology, Perth, Western Australia, Australia.
¹⁵ Kingsway Dermatology, Miranda, New South Wales, Australia.
¹⁶ The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

PMID: 31529493
DOI: 10.1111/ajd.13141

Abstract

With the rapid development of new, targeted therapies for the treatment of moderate/severe atopic dermatitis, it is opportune to review the available conventional systemic agents. We assess the published evidence for systemic therapies for atopic dermatitis and amalgamate this with real-world experience. Discussions are centred on when systemic therapy should be considered, which drug(s), what dose, how to sequence or combine these therapies, how long they should be continued for and what is considered success.

Keywords: atopic dermatitis; atopic eczema; azathioprine; biologic therapies; ciclosporin; corticosteroids; methotrexate; mycophenolate; second-line therapy; small molecules; systemic treatment.

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References

1. LePoidevin LM, Lee DE, Shi VY. A comparison of international management guidelines for atopic dermatitis. Pediatr. Dermatol. 2019; 36: 36-65.
1. Sidbury R, Kodama S. Atopic dermatitis guidelines: diagnosis, systemic therapy, and adjunctive care. Clin. Dermatol. 2018; 36: 648-52.
1. Wollenberg A, Barbarot S, Bieber T et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J. Eur. Acad. Dermatol. Venereol. 2018; 32: 657-82.
1. Wollenberg A, Barbarot S, Bieber T et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. J. Eur. Acad. Dermatol. Venereol. 2018; 32: 850-78.
1. de María Díaz Granados L, Quijano MA, Ramírez PA et al. Quality assessment of atopic dermatitis clinical practice guidelines in ≤ 18 years. Arch. Dermatol. Res. 2018; 310: 29-37.

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Managing atopic dermatitis with systemic therapies in adults and adolescents: An Australian/New Zealand narrative

Affiliations

Managing atopic dermatitis with systemic therapies in adults and adolescents: An Australian/New Zealand narrative

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources