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Review
. 2019 Oct 7;58(41):14428-14437.
doi: 10.1002/anie.201908308. Epub 2019 Sep 17.

Phage Display: Simple Evolution in a Petri Dish (Nobel Lecture)

George P Smith  1
Affiliations
Review

Phage Display: Simple Evolution in a Petri Dish (Nobel Lecture)

George P Smith. Angew Chem Int Ed Engl. .

Abstract

Playing with evolution: In his Nobel lecture, George P. Smith reconstructs the story of the phage-display idea as he personally experienced it. The development of this technique is a case study in how a scientific advance emerges gradually in incremental steps within overlapping global scientific communities.

Keywords: Nobel lecture; affinity selection; peptide library; phage display.

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References

    1. “Phage Display”: G. P. Smith, V. A. Petrenko, Chem. Rev. 1997, 97, 391-410.
    1. G. P. Smith, Nobel Lecture in Chemistry, 2018: Phage display: simple evolution in a Petri dish (https://www.nobelprize.org/prizes/chemistry/2018/smith/lecture/) (Stockholm, Sweden, Nobel Foundation).
    1. “Gene-III protein of filamentous phages: evidence for a carboxyl-terminal domain with a role in morphogenesis”: J. W. Crissman, G. P. Smith, Virology 1984, 132, 445-455.
    1. “Filamentous phage DNA cloning vectors: a noninfective mutant with a nonpolar deletion in gene III”: F. K. Nelson, S. M. Friedman, G. P. Smith, Virology 1981, 108, 338-350.
    1. “Domain structure of bacteriophage fd adsorption protein”: J. Armstrong, R. N. Perham, J. E. Walker, FEBS Lett. 1981, 135, 167-172.

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