Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Oct 7;58(41):14438-14445.
doi: 10.1002/anie.201909343. Epub 2019 Sep 17.

Harnessing Evolution to Make Medicines (Nobel Lecture)

Gregory Winter  1
Affiliations
Review

Harnessing Evolution to Make Medicines (Nobel Lecture)

Gregory Winter. Angew Chem Int Ed Engl. .

Abstract

Antibody libraries and phage display have provided the key elements for the creation of a fast evolutionary system for the generation of fully human antibody medicines. Important steps leading to this development are outlined by G. Winter in his Nobel lecture.

Keywords: antibodies; drug development; immune system; phage display.

PubMed Disclaimer

References

    1. “Man-made antibodies”: G. Winter, C. Milstein, Nature 1991, 349, 293-299.
    1. “Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions”: N. Hozumi, S. Tonegawa, Proc. Natl. Acad. Sci. USA 1976, 73, 3628-3632.
    1. “Structure and Function of Immunoglobulins”: H. W. Schroeder, L. Cavacini, J. Allergy Clin. Immunol. 2010, 125, S41-S52.
    1. “Continuous cultures of fused cells secreting antibody of predefined specificity”: G. Köhler, C. Milstein, Nature 1975, 256, 495-497.
    1. “Assembly of functional antibodies from immunoglobulin heavy and light chains synthesized in E. coli”: M. A. Boss, J. H. Kenten, C. R. Wood, J. S. Emtage, Nucleic Acids Res. 1984, 12, 3791-3806.

Substances

LinkOut - more resources