Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Aug 1;9(4):409-416.
doi: 10.31661/jbpe.v0i0.792. eCollection 2019 Aug.

Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan

Zaman M U  1 , Fatima N  1 , Mehdi S U  1 , Sami M  2 , Khan Kh  1 , Khan G  1
Affiliations

Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan

Zaman M U et al. J Biomed Phys Eng. .

Abstract

Background: Compact cyclotrons are getting popular to fulfill enormous current demands of PET tracers. Aga Khan University Hospital, Karachi, Pakistan has acquired the first smallest footprint of BG-75 Generator for 18FDG-based PET/CT clinical imaging. We are sharing our experience of BG-75 in the first year (December 2015-November 2016) after commissioning.

Material and methods: BG-75 Generator (ABT, USA) was installed in available space without major design modification. It has a self-shielded mini-cyclotron (7.5 MeV proton beam, positive ion with current < 5µA) to produce [18F]F-, an automated card-based radiochemistry module to produce 18FDG and automated QC module to perform tests upon each batch of 18FDG. Data were collected for yields of [18F]F-, 18FDG, QC and radiation safety parameters.

Results: Total 545 runs in 167 days (3±01 runs/day) were made. Average yield with 60 minute bombardment using 4.5 µA current was 37 mCi and 21 mCi for [18F]F- and 18FDG, respectively. Total 29 runs had chemistry or QC failures and were discarded. Remaining 516 batches were used to perform imaging upon 1370 patients (8±03 patients/day). Radiation dose in BG-75 suite and effective doses to 02 operators were within statutory limits.

Conclusion: BG-75 Generator provides safe, dependable and sustainable supply of 18F-Fluoride for 18FDG and other low-volume clinical PET imaging. Its compactness and automation need minimal space and manpower. Radiation dose rate in cyclotron suite and personal dosimetry were also found within safe limits. Its Dose-on-Demand workflow offers a new concept of Personalized Dose Preparation which is currently not possible with a conventional cyclotron.

Keywords: Fluorodeoxyglucose 18F; Cyclotron; Positron Emission Tomography Computed Tomography.

PubMed Disclaimer

Figures

Figure1
Figure1
Scatter plot of End of Bombardment (EoB) yield of F-18 against numbers of runs of cyclotron during study period.
Figure2
Figure2
Workflow of cyclotron from bombardment, radiochemistry and quality control of final 18FDG production for three successive runs of the cyclotron.
Figure3
Figure3
Scatter plot for number of patients performed with 18FDG doses against functional days of cyclotron.
See this image and copyright information in PMC

References

    1. Avril N E, Weber W A. Monitoring response to treatment in patients utilizing PET. Radiol Clin North Am. 2005;43:189–204. - PubMed
    1. Uz Zaman M, Fatima N, Sajjad Z, Zaman U, Tahseen R, Zaman A. 18FDG synthesis and supply: a journey from existing centralized to future decentralized models. Asian Pac J Cancer Prev. 2014;15:10057–9. - PubMed
    1. Hamacher K, Coenen H H, Stöcklin G. Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. 1986;27:235–8. - PubMed
    1. U.S. Pharmacopeial Convention, U.S. Pharmacopeia 36th ed., The National Formulary 31st ed., General Chapter 714 Sterility Tests, 2013 .
    1. Boellaard R, Delgado-Bolton R, Oyen W J, Giammarile F, Tatsch K, Eschner W, et al. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging. 2015;42:328–54. doi: 10.1007/s00259-014-2961-x. [ PMC Free Article] - DOI - PMC - PubMed

LinkOut - more resources