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. 2019 Dec;60(6):716-723.
doi: 10.1002/mus.26706. Epub 2019 Oct 23.

Prognostic factors for the sequelae and severity of Guillain-Barré syndrome in children

Sophie Estrade  1 , Clara Guiomard  1 , Vincent Fabry  2 , Eloise Baudou  1 , Claude Cances  1 , Yves Chaix  1 , Pascal Cintas  2 , Pierre Meyer  3   4 , Emmanuel Cheuret  1
Affiliations

Prognostic factors for the sequelae and severity of Guillain-Barré syndrome in children

Sophie Estrade et al. Muscle Nerve. 2019 Dec.

Abstract

Introduction: Guillain-Barré syndrome (GBS) is an inflammatory polyradiculoneuritis. Our aim in this study was to describe the clinical characteristics and the long-term sequelae of GBS in a French pediatric population.

Methods: In this multicenter, retrospective study we evaluated clinical signs, radiological examinations, laboratory tests, treatments, and outcomes.

Results: One hundred ten children were included in this investigation. These children presented with walking difficulties, muscle weakness, and cranial nerve impairment. Electrodiagnostic testing revealed 70% with acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and 16% with acute motor axonal neuropathy (AMAN). One hundred children received immunoglobulins. At follow-up, 77% were cured, whereas 9% had sequelae, associated with an axonal form (P < .01) and a short interval between symptom onset and hospitalization (P < .01). The need for intubation was correlated with peripheral facial paralysis (P < .01) and dysautonomia (P < .01).

Discussion: Although AIDP and AMAN present in a similar way, the axonal form is associated with a worse outcome.

Keywords: Guillain-Barré syndrome; children; dysautonomia; outcome; sequelae.

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References

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