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. 1979 Oct;37(2):309-16.
doi: 10.1007/BF00237716.

Dopamine-mediated circling behaviour does not involve the nigro-tectal pathway

C Reavill, N Leigh, P Jenner, C D Marsden

Dopamine-mediated circling behaviour does not involve the nigro-tectal pathway

C Reavill et al. Exp Brain Res. 1979 Oct.

Abstract

Extensive unilateral or bilateral electrolytic ablation of the rat superior colliculus failed to reduce apomorphine- or amphetamine-induced rotation in animals with a unilateral 6-hydroxydopamine lesion of one nigro-striatal dopaminergic pathway. These findings suggest that a nigro-tectal pathway does not play a crucial role in mediating the circling response caused by striatal dopamine receptor stimulation. However, electrolytic lesions of the dorsal tegmental decussation reduced apomorphine- but not amphetamine-induced rotation in such animals, perhaps by sectioning some commissural pathway between the two nigro-striatal systems.

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References

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