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Comment
. 2019 Sep 17;51(3):415-417.
doi: 10.1016/j.immuni.2019.08.019.

Why Is IFN-λ Less Inflammatory? One IRF Decides

Rebecca L Casazza  1 , Helen M Lazear  2
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Why Is IFN-λ Less Inflammatory? One IRF Decides

Rebecca L Casazza et al. Immunity. .
Free article

Abstract

Type I and type III interferons (IFNs) activate similar antiviral transcriptional programs, but the type I IFN response is more inflammatory. In this issue of Immunity, Forero et al. find that selective induction of the transcription factor IRF1 promotes proinflammatory chemokine expression downstream of type I IFN signaling.

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