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Comment
. 2019 Sep 17;51(3):420-423.
doi: 10.1016/j.immuni.2019.08.018.

Scoring a HAT-Trick against Lymphoma

Oliver Bannard  1
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Scoring a HAT-Trick against Lymphoma

Oliver Bannard. Immunity. .
Free article

Abstract

The genes encoding the histone acetyltransferases (HATs) CREBB-binding protein (CREBBP) and EP300 are commonly mutated in germinal-center-derived B cell lymphomas, and their inactivation is thought to contribute to lymphomagenesis. In this issue of Immunity, Meyer et al. (2019) demonstrate that the somatic inactivation of one histone modifying enzyme might leave lymphomas uniquely sensitive to antagonists of the other.

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