Q&A: Keeping antivirals viable

Comment

Naomi Lubick. Nature. 2019 Sep.

. 2019 Sep;573(7774):S53.

doi: 10.1038/d41586-019-02752-9.

No abstract available

Keywords: Diseases; Drug discovery; Ecology; Therapeutics.

Comment on

Antiviral drugs in wastewater and surface waters: a new pharmaceutical class of environmental relevance?
Prasse C, Schlüsener MP, Schulz R, Ternes TA. Prasse C, et al. Environ Sci Technol. 2010 Mar 1;44(5):1728-35. doi: 10.1021/es903216p. Environ Sci Technol. 2010. PMID: 20108960
Environmental levels of the antiviral oseltamivir induce development of resistance mutation H274Y in influenza A/H1N1 virus in mallards.
Järhult JD, Muradrasoli S, Wahlgren J, Söderström H, Orozovic G, Gunnarsson G, Bröjer C, Latorre-Margalef N, Fick J, Grabic R, Lennerstrand J, Waldenström J, Lundkvist A, Olsen B. Järhult JD, et al. PLoS One. 2011;6(9):e24742. doi: 10.1371/journal.pone.0024742. Epub 2011 Sep 12. PLoS One. 2011. PMID: 21931841 Free PMC article.
Oseltamivir-resistant influenza A (H1N1) virus strain with an H274Y mutation in neuraminidase persists without drug pressure in infected mallards.
Gillman A, Muradrasoli S, Söderström H, Holmberg F, Latorre-Margalef N, Tolf C, Waldenström J, Gunnarsson G, Olsen B, Järhult JD. Gillman A, et al. Appl Environ Microbiol. 2015 Apr;81(7):2378-83. doi: 10.1128/AEM.04034-14. Epub 2015 Jan 23. Appl Environ Microbiol. 2015. PMID: 25616792 Free PMC article.