Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Aug 25:2019:3685264.
doi: 10.1155/2019/3685264. eCollection 2019.

Medicinal Plants from Brazilian Cerrado: Antioxidant and Anticancer Potential and Protection against Chemotherapy Toxicity

José Tarcísio de Giffoni de Carvalho  1 , Débora da Silva Baldivia  1 , Daniel Ferreira Leite  1 , Laura Costa Alves de Araújo  1 , Priscilla Pereira de Toledo Espindola  1 , Katia Avila Antunes  1 , Paola Santos Rocha  1 , Kely de Picoli Souza  1 , Edson Lucas Dos Santos  1
Affiliations
Review

Medicinal Plants from Brazilian Cerrado: Antioxidant and Anticancer Potential and Protection against Chemotherapy Toxicity

José Tarcísio de Giffoni de Carvalho et al. Oxid Med Cell Longev. .

Abstract

The use of natural antioxidants in cancer therapy has increased: first, due to the potential of natural antioxidants to kill tumour cells and second, because of their capacity to protect healthy cells from the damage caused by chemotherapy. This review article discusses the antioxidant properties of extracts obtained from medicinal plants from the Brazilian Cerrado and the cell death profile induced by each of these extracts in malignant cells. Next, we describe the capacity of other medicinal plants from the Cerrado to protect against chemotherapy-induced cell toxicity. Finally, we focus on recent insights into the cell death profile induced by extracts from Cerrado plants and perspectives for future therapeutic approaches.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Cell death profile induced by extracts and/or compounds from medicinal plants of Cerrado.
See this image and copyright information in PMC

References

    1. Katz L., Baltz R. H. Natural product discovery: past, present, and future. Journal of Industrial Microbiology & Biotechnology. 2016;43(2-3):155–176. doi: 10.1007/s10295-015-1723-5. - DOI - PubMed
    1. Newman D. J., Cragg G. M. Natural products as sources of new drugs from 1981 to 2014. Journal of Natural Products. 2016;79(3):629–661. doi: 10.1021/acs.jnatprod.5b01055. - DOI - PubMed
    1. Florian S., Mitchison T. J. Anti-microtubule drugs. In: Chang P., Ohi R., editors. Mitotic Spindle Methods Protoc. New York, NY: Springer New York; 2016. pp. 403–421. cited 2019 Feb 28. - DOI - PubMed
    1. Xu D.-P., Li Y., Meng X., et al. Natural antioxidants in foods and medicinal plants: extraction, assessment and resources. International Journal of Molecular Sciences. 2017;18(1):p. 96. doi: 10.3390/ijms18010096. - DOI - PMC - PubMed
    1. Khansari N., Shakiba Y., Mahmoudi M. Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Patents on Inflammation & Allergy Drug Discovery. 2009;3(1):73–80. doi: 10.2174/187221309787158371. - DOI - PubMed

MeSH terms