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Review
. 2020 Jan;50(1):12-20.
doi: 10.1007/s00595-019-01878-7. Epub 2019 Sep 18.

Recent progress in multidisciplinary treatment for patients with esophageal cancer

Masayuki Watanabe  1 , Reiko Otake  2 , Ryotaro Kozuki  2 , Tasuku Toihata  2 , Keita Takahashi  2 , Akihiko Okamura  2 , Yu Imamura  2
Affiliations
Review

Recent progress in multidisciplinary treatment for patients with esophageal cancer

Masayuki Watanabe et al. Surg Today. 2020 Jan.

Erratum in

Abstract

Esophageal cancer is one of the most aggressive gastrointestinal cancers. This review focuses on eight topics within the multidisciplinary approach for esophageal cancer. As esophagectomy is highly invasive and likely to impair quality of life, the development of less invasive strategies is expected. Endoscopic resection (ER) of early esophageal cancer is a less invasive treatment for early esophageal cancer. A recent phase II trial revealed that combined ER and chemoradiotherapy (CRT) is efficacious as an esophagus-preserving treatment for cT1bN0 squamous cell carcinoma (SCC). Esophagectomy and definitive CRT are equally effective for patients with clinical stage I SCC in terms of long-term outcome. For locally advanced resectable cancers, multidisciplinary treatment strategies have been established through several clinical trials of neoadjuvant or perioperative treatment. Minimally invasive esophagectomy may improve the outcomes of patients and CRT is a curative-intent alternative to esophagectomy. CRT with 50.4 Gy radiotherapy combined with salvage surgery is a promising option to preserve the esophagus. Induction chemotherapy followed by esophagectomy may improve the outcomes of patients with locally advanced unresectable tumors. Immune checkpoint inhibitors are effective for esophageal cancer, and their introduction to clinical practice is awaited.

Keywords: Chemoradiotherapy; Esophageal cancer; Esophagectomy; Multidisciplinary treatment.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

References

    1. Pennathur A, Gibson MK, Jobe BA, Luketich JD. Oesophageal carcinoma. Lancet. 2013;381:400–412. doi: 10.1016/S0140-6736(12)60643-6. - DOI - PubMed
    1. Center of Cancer Control and Information Services NCC. Cancer Statistics in Japan, Cancer Information Service. 2019. https://ganjoho.jp/en/professional/statistics/table_download.html. Accessed 10 Aug.
    1. Huang F-L, Yu S-J. Esophageal cancer: risk factors, genetic association, and treatment. Asian J Surg. 2018;41:210–215. doi: 10.1016/j.asjsur.2016.10.005. - DOI - PubMed
    1. Watanabe M. Recent topics and perspectives on esophageal cancer in Japan. JMA J. 2018;1:30–39. doi: 10.31662/jmaj.2018-0002. - DOI - PMC - PubMed
    1. Takeuchi H, Miyata H, Gotoh M, Kitagawa Y, Baba H, Kimura W, et al. A risk model for esophagectomy using data of 5354 patients included in a Japanese nationwide web-based database. Ann Surg. 2014;260:259–266. doi: 10.1097/SLA.0000000000000644. - DOI - PubMed