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Comparative Study
. 2019 Nov;36(11):3166-3173.
doi: 10.1007/s12325-019-01091-5. Epub 2019 Sep 18.

Duration of Dual Antiplatelet Therapy and Late Stent Thrombosis Following Percutaneous Coronary Intervention with Second-Generation Drug-Eluting Stents: A Simple Meta-Analysis of Randomized Controlled Trials

Bei-You Lin  1 , Ping Li  2 , Peng Wu  1 , Ri-Na Jiang  1 , Pravesh Kumar Bundhun  3 , Mohamad Anis Ahmed  4
Affiliations
Comparative Study

Duration of Dual Antiplatelet Therapy and Late Stent Thrombosis Following Percutaneous Coronary Intervention with Second-Generation Drug-Eluting Stents: A Simple Meta-Analysis of Randomized Controlled Trials

Bei-You Lin et al. Adv Ther. 2019 Nov.

Abstract

Introduction: The aim of this simple meta-analysis was to systematically compare the occurrence of late and very late stent thrombosis with a short versus a longer duration of dual anti-platelet therapy (DAPT) use following the implantation of second-generation drug-eluting stents (DES).

Methods: Randomized controlled trials that compared short- and long-term DAPT use following percutaneous coronary intervention (PCI) with DES and that reported late (> 30 days but < 1 year) and very late (> 1 year) stent thromboses were searched from the bibliographic database of life sciences and biomedical information, which is also known as MEDLINE, as well as other searched databases including EMBASE, the Cochrane Central and http://www.ClinicalTrials.com . Statistical analysis was carried out using RevMan software [odds ratios (OR) and 95% confidence intervals (CIs) represented the results].

Results: This simple analysis consisted of five randomized controlled trials with a total of 7142 patients. The current results showed no significant difference in late stent thrombosis associated with a shorter or longer duration of DAPT use (OR 0.98, 95% CI 0.30-3.18; P = 0.97, I2 = 0%). The result for very late stent thrombosis was also not significantly different (OR 0.30, 95% CI 0.03-2.95; P = 0.31).

Conclusions: This simple analysis showed no impact of DAPT duration on the occurrence of late and very late stent thrombosis. Similar late and very late stent thrombosis rates were observed with 6-month versus 12-month duration of DAPT use following PCI with second-generation DES.

Keywords: Cardiology; Coronary angioplasty; Dual antiplatelet therapy; Late stent thrombosis; Second-generation drug-eluting stents.

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Figures

Fig. 1
Fig. 1
Study selection represented through this flow diagram
Fig. 2
Fig. 2
Comparing the occurrence of late stent thrombosis with a short versus longer duration of DAPT use
Fig. 3
Fig. 3
Comparing the occurrence of very late stent thrombosis with short versus longer duration of DAPT use
Fig. 4
Fig. 4
Publication bias represented in a funnel plot
See this image and copyright information in PMC

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