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Review
. 2019 Sep 19;15(9):e1007977.
doi: 10.1371/journal.ppat.1007977. eCollection 2019 Sep.

Emergomyces: The global rise of new dimorphic fungal pathogens

Ilan S Schwartz  1 , Nelesh P Govender  2   3 , Lynne Sigler  4 , Yanping Jiang  5   6 , Tsidiso G Maphanga  2   7 , Barbra Toplis  8 , Alfred Botha  8 , Karolina Dukik  5 , J Claire Hoving  9 , Jose F Muñoz  10 , Sybren de Hoog  5   11 , Christina A Cuomo  10 , Robert Colebunders  12 , Chris Kenyon  13   14
Affiliations
Review

Emergomyces: The global rise of new dimorphic fungal pathogens

Ilan S Schwartz et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Global geographic distribution of reported cases of emergomycosis [, –, –, –30].
Each icon represents a single case except for Emergomyces africanus in South Africa, as indicated. Map created by Institute of Tropical Medicine, Antwerp.
Fig 2
Fig 2. Potential model for exposure and pathogenesis of Emergomyces.
1) Emergomyces species exist in soil in a mold phase, from where 2) conidia are released and aerosolized. 3) Upon inhalation by humans, the conidia undergo a temperature-dependent transformation in the lungs to yeast-like cells that replicate by budding and are capable of causing pulmonary disease in susceptible individuals. 4) Yeast-like cells disseminate hematogenously in macrophages throughout the body, causing extrapulmonary disease. 5) Cutaneous disease is most frequently reported, although virtually any body site can be affected.
See this image and copyright information in PMC

References

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