Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jun;105(6):e294-e297.
doi: 10.3324/haematol.2019.225078. Epub 2019 Sep 19.

Unique clinico-biological, genetic and prognostic features of adult early T-cell precursor acute lymphoblastic leukemia

Eulàlia Genescà  1 , Mireia Morgades  2 , Pau Montesinos  3 , Pere Barba  4 , Cristina Gil  5 , Ramon Guàrdia  6 , María-José Moreno  7 , Daniel Martínez-Carballeira  8 , Irene García-Cadenas  9 , Susana Vives  2 , Jordi Ribera  10 , José González-Campos  11 , Celia González-Gil  10 , Lurdes Zamora  2 , José-Luís Ramírez  2 , Marina Díaz-Beya  12 , Santiago Mercadal  13 , María-Teresa Artola  14 , Antònia Cladera  15 , Mar Tormo  16 , Arancha Bermúdez  17 , Ferran Vall-Llovera  18 , Pilar Martínez  19 , María-Luz Amigo  20 , Silvia Monsalvo  21 , Andrés Novo  22 , Marta Cervera  23 , Antoni García-Guiñon  24 , Jordi Juncà  2 , Juana Ciudad  25 , Alberto Orfao  25 , Josep-Maria Ribera  10   2
Affiliations

Unique clinico-biological, genetic and prognostic features of adult early T-cell precursor acute lymphoblastic leukemia

Eulàlia Genescà et al. Haematologica. 2020 Jun.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Impact of allogeneic hematopoietic stem cell transplantation on overall survival of patients with or without early T-cell precursor acute lymphoblastic leukemia. (A) Overall survival of adults with early T-cell precursor acute lymphoblastic leukemia (ETP-ALL) vs. other non-ETP T-ALL adult patients censored at transplantation; the survival probability, with 95% confidence interval (95% CI) at 4 years was 36% (95% CI: 13-59%) for the ETP-ALL group and 49% (95% CI: 39-59%) for the other non-ETP patients. (B) Overall survival of ETP and non-ETP T-ALL patients not censored at transplantation. The survival probability at 4 years was 33% (95% CI: 16-50%) for ETP-ALL patients vs. 51% (95% CI: 42-60%) for the non-ETP T-ALL group.
See this image and copyright information in PMC

References

    1. Coustan-Smith E, Mullighan CG, Onciu M, et al. Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol. 2009;10(2):147–156. - PMC - PubMed
    1. Zuurbier L, Gutierrez A, Mullighan CG, et al. Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors. Haematologica. 2014;99(1):94–102. - PMC - PubMed
    1. Neumann M, Heesch S, Gokbuget N, et al. Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations. Blood Cancer J. 2012;2(1):e55. - PMC - PubMed
    1. Neumann M, Coskun E, Fransecky L, et al. FLT3 mutations in early T-cell precursor ALL characterize a stem cell like leukemia and imply the clinical use of tyrosine kinase inhibitors. PLoS One. 2013;8(1):e53190. - PMC - PubMed
    1. Zhang J, Ding L, Holmfeldt L, et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 2012;481(7380):157–163. - PMC - PubMed

Publication types

MeSH terms