Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Apr;34(4):611-613.
doi: 10.1038/s41433-019-0583-z. Epub 2019 Sep 19.

Brolucizimab-leading an era of structural revolution for long-term VEGF suppression

Affiliations

Brolucizimab-leading an era of structural revolution for long-term VEGF suppression

Ashish Sharma et al. Eye (Lond). 2020 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Variation in molecular structure of originator biologics used in ophthalmology

References

    1. Keane PA, Sadda SR. Development of anti-VEGF therapies for intraocular use: a guide for clinicians. J Ophthalmol. 2012;2012:1–13. - PMC - PubMed
    1. Bates A, Power CA. Goliath: the structure, function, and clinical prospects of antibody fragments. Antibodies. 2019;8:28. - PMC - PubMed
    1. Dugel PU, Koh A, Ogura Y, Jaffe GJ, Schmidt-Erfurth U, Brown DM, et al. HAWK and HARRIER: phase 3, multicenter, randomized, double-masked trials of brolucizumab for neovascular age-related macular degeneration. Ophthalmology. 2019; pii: S0161-6420(18)33018-5. - PubMed
    1. Kholodenko RV, Kalinovsky DV, Doronin II, Ponomarev ED, Kholodenko IV. Antibody fragments as potential biopharmaceuticals for cancer therapy: success and limitations. Curr Med Chem. 2019;26:396–426. - PubMed
    1. Amadio M, Govoni S, Pascale A. Targeting VEGF in eye neovascularization: what’s new? Pharmacol Res. 2016;103:253–69. - PubMed

Substances