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. 2019 Sep;62(5):344-351.
doi: 10.5468/ogs.2019.62.5.344. Epub 2019 Jul 23.

Scheduled injection of ramosetron for prevention of nausea and vomiting following single-port access total laparoscopic hysterectomy: a prospective randomized study

Shoou-Chern Li  1 , Youngmi Wang  1 , Seong Jin Choi  1 , Yeon Soo Jung  1 , Kyoung-Hee Han  1 , In Bai Chung  1 , San-Hui Lee  1   2
Affiliations

Scheduled injection of ramosetron for prevention of nausea and vomiting following single-port access total laparoscopic hysterectomy: a prospective randomized study

Shoou-Chern Li et al. Obstet Gynecol Sci. 2019 Sep.

Abstract

Objective: The purpose of this study was to evaluate the effectiveness of scheduled ramosetron injections for controlling postoperative nausea and vomiting (PONV) after single-port access total laparoscopic hysterectomy (SPA-TLH).

Methods: Ninety patients who underwent SPA-TLH at the Korean National Health Insurance Service Ilsan Hospital between June 2013 and July 2014 were enrolled in this prospective, randomized, double-blinded, placebo-controlled study. The patients were divided into 2 groups as follows: the ramosetron group (0.3 mg intravenously [IV]; n=45) and the placebo group (normal saline IV; n=45). Both groups received their respective injections 12 and 24 hours post surgery. The incidence and severity of PONV (numerical rating scale, 0-10), and the use of rescue antiemetics post surgery were evaluated.

Results: Demographic and perioperative statistically significant differences were not observed between the 2 groups. The incidence of PONV in the ramosetron and placebo groups was 46.7% and 51.1%, respectively (P=0.51). We found significant differences in the severity of PONV between the 24- to 48-hour postoperative periods in both groups (ramosetron group, P=0.04 and placebo group, P=0.03). The use of rescue antiemetics was significantly lower in the ramosetron group than in the placebo group (P=0.02).

Conclusion: After general anesthesia, scheduled injections of ramosetron 12 and 24 hours after SPA-TLH reduced the severity of PONV and the use of rescue antiemetics. Administration of ramosetron can be considered not only immediately after SPA-TLH but also during the first 24-hour recovery period.

Trial registration: ClinicalTrials.gov Identifier: NCT02011659.

Keywords: Hysterectomy; Laparoscopy; Postoperative nausea and vomiting; Ramosetron.

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Conflict of interest statement

Conflict of interest: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Flowchart.
IV, intravenously.
Fig. 2
Fig. 2. Incidence of postoperative nausea and vomiting based on time points.
See this image and copyright information in PMC

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