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. 2019 Aug 23;6(7):541-546.
doi: 10.1002/mdc3.12808. eCollection 2019 Sep.

Movement Disorder Society Task Force Viewpoint: Huntington's Disease Diagnostic Categories

Christopher A Ross  1 , Ralf Reilmann  2 , Francisco Cardoso  3 , Elizabeth A McCusker  4 , Claudia M Testa  5 , Julie C Stout  6 , Blair R Leavitt  7 , Zhong Pei  8 , Bernhard Landwehrmeyer  9 , Asuncion Martinez  10 , Jamie Levey  11   12 , Teresa Srajer  10 , Jee Bang  13 , Sarah J Tabrizi  14   15
Affiliations

Movement Disorder Society Task Force Viewpoint: Huntington's Disease Diagnostic Categories

Christopher A Ross et al. Mov Disord Clin Pract. .
No abstract available

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Conflict of interest statement

No relevant funding sources or conflicts of interest, given the nature of the article. No off‐label uses of medications or other treatments discussed. Participants received financial support for travel to the meeting February 4 and 5, 2017, from the Movement Disorder Society. Costs for phone conferences were paid by the Movement Disorder Society.

Figures

Figure 1
Figure 1
Diagnostic categories defined in this paper in the context of Huntington's disease (HD) natural history. The Cytosine, Adenine, Guanine (CAG) expansion in the Huntingtin gene is present at birth, and the mRNA and protein are widely expressed during development and adulthood, so the biological processes underlying the clinical syndrome are continuously active during the individual's lifetime. The extent of exposure to the effects of the CAG expansion can be quantified using the CAG age product (CAP) score (see text). The “premanifest HD” period before diagnosable onset according to the criteria proposed includes both the “presymptomatic HD” period, when there are no detectable clinical features, and the prodromal HD period, when there are subtle changes in motor and cognitive (and often emotional) function, with consequent subtle changes in functional abilities. During the manifest HD period, the motor and cognitive features progress, and functional abilities decline.
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