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. 2019 Aug 15:4:e208-e214.
doi: 10.5114/amsad.2019.87305. eCollection 2019.

The role of kidney injury molecule-1 in predicting cardiorenal syndrome type 1 after diuretic treatment

Adem Atici  1 , Samim Emet  1 , Ilkim Deniz Toprak  2 , Ramazan Cakmak  3 , Murat Akarsu  4 , Tufan Tukek  3
Affiliations

The role of kidney injury molecule-1 in predicting cardiorenal syndrome type 1 after diuretic treatment

Adem Atici et al. Arch Med Sci Atheroscler Dis. .

Abstract

Introduction: Cardiorenal syndrome (CRS) is defined as acute or chronic dysfunction in the heart and kidney due to important interactions between the heart and kidney disease. The aim of this study was to evaluate prediction of CRS type 1 by measuring kidney injury molecule-1 (KIM-1) and to establish early diagnosis of acute kidney injury (AKI).

Material and methods: During 2015-2016, 146 patients who were admitted to the emergency service with acute decompensated HF were included in the study. We investigated urinary KIM-1 levels in 146 consecutive patients with decompensated heart failure before and after diuretic treatment. Statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS - version 21.0)/Windows Statistical Software. P-values less than < 0.05 were considered significant.

Results: There was a moderate negative correlation between the percentage change of creatinine values and the percentage change of KIM-1 values (r = -0.357, p = 0.016). There was no statistically significant relationship between KIM-1 and the development of CRS type 1 (p = 0.011).

Conclusions: No statistically significant relationship was observed between KIM-1 levels and the development of CRS type 1. In addition, there was no correlation between mortality in patients and KIM-1 values. It is thought that KIM-1 is not a potential prognostic indicator because renal tubular damage is only one of many factors in the pathophysiology of CRS type 1 and heart failure.

Keywords: acute kidney injury; cardiorenal syndrome; kidney injury molecule-1.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of baseline KIM-1 values in patients with and without cardiorenal syndrome
Figure 2
Figure 2
Relationship between creatinine levels and KIM-1 (The blue bar represents creatinine and the green bar represents KIM-1)
Figure 3
Figure 3
Effect of diuretic dose on KIM-1
See this image and copyright information in PMC

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